Results 41 to 50 of about 266,324 (188)

How a protein searches for its specific site on DNA: the role of intersegment transfer [PDF]

Phys. Rev. E 76, 051909 (2007)., 2007
Proteins are known to locate their specific targets on DNA up to two orders of magnitude faster than predicted by the Smoluchowski three-dimensional diffusion rate. One of the mechanisms proposed to resolve this discrepancy is termed "intersegment transfer".
arxiv   +1 more source

Selective Cholesterol Dynamics between Lipoproteins and Caveolae/Lipid Rafts [PDF]

, 2007
Although low-density lipoprotein (LDL) receptor-mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecular details and organizing principles for selective cholesterol uptake/efflux (reverse cholesterol transport, RCT ...
Atshaves, Barbara P., Ball, Judith M., Gallegos, Adalberto M., Kier, Ann B., Landrock, Kerstin K., Martin, Gregory G., McIntosh, Avery L., Parr, Rebecca D., Schroeder, Friedhelm, Storey, Stephen M.   +9 more
core   +2 more sources

Non‐Alcoholic Fatty Liver Disease: The Bile Acid‐Activated Farnesoid X Receptor as an Emerging Treatment Target

Journal of Lipids, Volume 2012, Issue 1, 2012., 2012
Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to represent the most common indication for liver transplantation in the near future.
Michael Fuchs, Piero Portincasa
wiley   +1 more source

Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells [PDF]

, 2012
Background: The plasma cholesterol and triacylglycerol lowering effects of Tamarindus indica extract have been previously described. We have also shown that the methanol extract of T.
A Raz, A Subramanian, AS Iftekhar, Azlina Abdul-Aziz, B Bibitha, F Martinello, GA Hagen, H Stenmark, J Agola, J John, JW Chisholm, LM Higa, M Holtta-Vuori, M Zerial, MA Liz, MD Linder, MR Metwali, N Razali, Onn Haji Hashim, P Bottoni, PM Ohnsorg, PT Chan, Puteri Shafinaz Abdul-Rahman, R Jiao, RE Soccio, Rizwan Hasan Khan, Sarni Mat Junit, SL Aleshire, SR Pfeffer, SR Pfeffer, Ursula Rho Wan Chong, V Pancholi, Y Benjamini, Y Sudjaroen   +33 more
core   +2 more sources

Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile [PDF]

, 2019
According to the current dogma, cholesteryl ester transfer protein (CETP) decreases high-density lipoprotein (HDL)-cholesterol (C) and increases low-density lipoprotein (LDL)-C. However, detailed insight into the effects of CETP on lipoprotein subclasses
Berbee, Jimmy F. P., Blauw, C. Alexander, Blauw, Lisanne L., de Mutsert, Renee, Jukema, J. Wouter, Li-Gao, Ruifang, Mook-Kanamori, Dennis O., Noordam, Raymond, Rensen, Patrick C. N., Rosendaal, Frits R., Soidinsalo, Sebastian, van Dijk, Ko Willems, van Heemst, Diana, Wang, Yanan, Wurtz, Peter   +14 more
core   +1 more source

HDL biogenesis revisited: how desmocollin-1 could sabotage reverse cholesterol transport in the arterial wall.

European Heart Journal, 2018
High-density lipoproteins (HDLs) are highly heterogeneous complexes of hundreds of lipids and 100 proteins that can be classified according to their composition, intrinsic density, size, and functions.
D. Rhainds, Mathieu R. Brodeur, Y. Rautureau, J. Tardif   +3 more
semanticscholar   +1 more source

Retrieved Sequence Augmentation for Protein Representation Learning [PDF]

arXiv, 2023
Protein language models have excelled in a variety of tasks, ranging from structure prediction to protein engineering. However, proteins are highly diverse in functions and structures, and current state-of-the-art models including the latest version of AlphaFold rely on Multiple Sequence Alignments (MSA) to feed in the evolutionary knowledge.
arxiv  

Unending saga of fighting cholesterol: Evacetrapib is another fallen warrior.

Bratislava Medical Journal, 2016
Despite an enormous success in reducing morbidity and mortality in cardiovascular disease (CVD), statins and modern antihypertensive medications are not universally effective. Research has focused on potential molecular targets in dyslipidemia.
V. Simko
semanticscholar   +1 more source

Sequence composition and environment effects on residue fluctuations in protein structures [PDF]

, 2009
The spectrum and scale of fluctuations in protein structures affect the range of cell phenomena, including stability of protein structures or their fragments, allosteric transitions and energy transfer. The study presents a statistical-thermodynamic analysis of relationship between the sequence composition and the distribution of residue fluctuations ...
arxiv   +1 more source

Dynamic compartmentalization of bacteria: accurate division in E. coli [PDF]

Physical Review Letters, v87, p278102 (2001)., 2001
Positioning of the midcell division plane within the bacterium E. coli is controlled by the min system of proteins: MinC, MinD and MinE. These proteins coherently oscillate from end to end of the bacterium. We present a reaction--diffusion model describing the diffusion of min proteins along the bacterium and their transfer between the cytoplasmic ...
arxiv   +1 more source