Results 201 to 210 of about 285,894 (338)

Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2017
Xiangning Li, Bin Yu, Qingtao Sun, Yalun Zhang, Miao Ren, Xiaoyan Zhang, Anan Li, Jing Yuan, L. Madisen, Qingming Luo, Hongkui Zeng, H. Gong, Z. Qiu   +12 more
semanticscholar   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum. [PDF]

Brain Commun
Jerele C, Tzortzakakis A, Nemy M, Rennie A, Arranz J, Montal V, Bejanin A, Aarsland D, Westman E, Fortea J, Lleó A, Alcolea D, Kramberger MG, Ferreira D.   +13 more
europepmc   +1 more source

The Epidemiology of Chronic Urticaria in Cape Town, South Africa: A Review of Two Tertiary Referral Centers

Allergy, EarlyView.
Cascia Day, Mimi Deetlefs, Lovemore Mapahla, Yejin Jang, Qiqa Gusha‐Mhlekude, Sicelo Ntuli, Balican Hlungwani, Susanna Kannenberg, Emma Kruger, Ndapewa Ambondo, Willem Visser, Thuraya Isaacs, Rannakoe Lehloenya, Jonny Peter   +13 more
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength. [PDF]

PLoS Biol
Shao J, Liewald JF, Steuer Costa W, Ruse C, Gruber J, Djamshedzad MS, Gebhardt W, Gottschalk A.   +7 more
europepmc   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

Chronic Chemogenetic Activation of Astrocytes in the Murine Mesopontine Region Leads to Disturbances in Circadian Activity and Movement. [PDF]

Int J Mol Sci
Maamrah B, Pocsai K, Hoang BM, Abdelhadi A, Al-Khafaji MQ, Csemer A, Sokvári C, Szentesi P, Pál B.   +8 more
europepmc   +1 more source

The C11orf24 Gene as a Useful Biomarker for Predicting Severe Neutropenia in Modified FOLFIRINOX for Pancreatic Cancer

Cancer Science, EarlyView.
FOLFIRINOX improves the prognosis of patients with pancreatic cancer; however, despite UGT1A1 screening, adverse events, such as severe neutropenia, occur frequently. The diagnostic performance of the neutropenia prediction model showed areas under the curve of 0.754 (sensitivity=0.605, specificity=0.848) and 0.856 (sensitivity=0.800, specificity=0.893)
Gen Kanesada, Ryouichi Tsunedomi, Yuki Nakagami, Hiroto Matsui, Yoshitaro Shindo, Shinobu Tomochika, Hirofumi Akita, Tatsuya Ioka, Hidenori Takahashi, Hiroaki Nagano   +9 more
wiley   +1 more source