Results 231 to 240 of about 51,688 (341)

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

open access: yesPrecision Medical Sciences, Volume 15, Issue 2, Page 147-159, June 2026.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim   +2 more
wiley   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan   +3 more
wiley   +1 more source

Mulberroside A: A Multi-Target Neuroprotective Agent in Alzheimer’s Disease via Cholinergic Restoration and PI3K/AKT Pathway Activation [PDF]

open access: gold
Jin Li   +9 more
openalex   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto   +7 more
wiley   +1 more source

Effect of inhaled anticholinergics on bronchial secretions: a systematic review. [PDF]

open access: yesFront Physiol
Arzayus-Patiño L   +4 more
europepmc   +1 more source

Control failure risk, resistance and enzymatic activity of neurotoxic insecticides in Brazilian populations of Leucoptera coffeella (Lepidoptera: Lyonetiidae)

open access: yesPest Management Science, Volume 82, Issue 6, Page 5757-5766, June 2026.
Bioassays of 36 Leucoptera coffeella populations revealed resistance to neurotoxic insecticides, control failures of ≤62.9% and enzyme activity variation, with particularly high GST and low AChE levels. Abstract Background Leucoptera coffeella is a key pest of coffee crops in Brazil, causing significant damage by mining coffee leaves.
Daianna P. Costa   +6 more
wiley   +1 more source

Alzheimer's disease drug development pipeline: 2026. [PDF]

open access: yesAlzheimers Dement (N Y)
Cummings JL   +6 more
europepmc   +1 more source

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