Results 241 to 250 of about 51,688 (341)

Effects of adrenaline, dopamine, serotonin, and different cholinergic agents on smooth muscle preparations of the proximal colon in cattle

, 1992
A.L. Steiner, M. Denac, U. Ballinari
openalex   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

Acta Crystallographica Section F, Volume 82, Issue 6, Page 201-207, June 2026.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima, Chiemi Mishima-Tsumagari, Mayumi Sakata-Sakuta, Ryo Iwaoka, Kunihiko Iwamoto   +4 more
wiley   +1 more source

Essential Oils: Chemistry and Mechanisms of Anticonvulsant Action. [PDF]

Int J Mol Sci
Salgueiro L, Zuzarte M, Emídio JJ, Fonsêca DVD, de Sousa DP.   +4 more
europepmc   +1 more source

Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol

, 2017
Phillip Simmers, S. Kevin Li, Gerald B. Kasting, Jason Heikenfeld   +3 more
openalex   +2 more sources

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Ginseng acetylcholine from various ginsengs and its <i>in vivo</i> physiological effect. [PDF]

J Ginseng Res
Lee R, Kim JH, Kim JU, Hwang SH, Nah SY.
europepmc   +1 more source

Fentanyl Compromises Lower‐Airway Mechanics and Naloxone Triggers a Transient Mechanical Overshoot

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the leading cause of death following opioid overdose, due to its effects on central rhythm generation, and airway and thoracic constriction. While the effects on rhythm generation have been well documented, the effects of fentanyl on airway constriction are less well understood. We tested the
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Madeline M. Johnson, Nicholas J. Burgraff   +4 more
wiley   +1 more source

Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department. [PDF]

Clin Case Rep
Tokioka K, Nojima T, Matsuo I, Tsukahara K, Nakao A.   +4 more
europepmc   +1 more source

Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations.

, 1990
Shigetoshi Chiba, Yasuyuki Karasawa, Kunio Akahane, Lei‐Ming Ren   +3 more
openalex   +2 more sources

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur, Mustafa Çeşme, Ferhan Tümer   +2 more
wiley   +1 more source