Results 61 to 70 of about 51,688 (341)

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

CHOLINERGIC NEUROPHARMACOLOGY - AN UPDATE

, 1991
The current status of the pharmacology of central cholinergic transmission is reviewed. Particular attention is paid to the compounds that have been or are potential candidates as therapeutic agents for the treatment of mental disorders, particularly ...
POMBOVILLAR, E, BODDEKE, HWGM, PALACIOS, JM   +2 more
core   +1 more source

On The Innervation of Salivary Glands and Treatment of Dry Mouth - An Experimental and Clinical Study

, 2009
Detailed knowledge of the innervation of the parotid gland is essential in basic studies on various neuroglandular phenomena as well as in various types of orofacial surgery. The innervation is more complex than usually depicted in Textbooks.
Khosravani, Nina
core   +1 more source

Dopaminergic novelty detection and theta oscillations: Virtual reality‐based adaptive interventions for cognitive enhancement in aging

Ibrain, EarlyView.
Aging‐related cognitive decline is associated with reduced dopaminergic signaling and disrupted theta oscillations, which together impair novelty detection and memory formation. This review shows how VR environments can be used to deliver adaptive, novelty‐rich stimuli that engage dopaminergic circuits and entrain theta rhythms, thereby enhancing ...
Abraham Olufemi Asuku, Ayodeji Johnson Ajibare   +1 more
wiley   +1 more source

Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice

Basic and Clinical Neuroscience, 2015
Introduction: Recent studies suggest that glucocorticoids modulate memory reconsolidation. Moreover, cholinergic system is involved in memory reconsolidation.
Somayeh Amiri, Zahra Jafarian, Abbas Ali Vafaei, Ali Rashidy-Pour, Zahra Motaghed larijani, Seyed Afshin Samaei   +5 more
doaj  

CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer’s disease in the Czech population

Journal of Biomedical Science, 2018
Background Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with Alzheimer’s disease.
Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar, Omar Šerý   +8 more
doaj   +1 more source

A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity

Frontiers in Computational Neuroscience, 2020
Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer's disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about
Adam Mergenthal, Jean-Marie C. Bouteiller, Gene J. Yu, Theodore W. Berger   +3 more
doaj   +1 more source

Effects of adolescent substance use disorders on central cholinergic function

, 2021
Adolescence is a transitional period between childhood and adulthood, in which the individual undergoes significant cognitive, behavioral, physical, emotional, and social developmental changes.
S.R. Hauser, Hauser, S.R., Deehan, Gerald A., Rodd, Z. A., Rodd, Z.A., T. Liang, Shafiqur Rahman, Hauser, S. R., Rahman, S., Deehan, G.A., Bell, Richard L., Rahman, Shafiqur, Richard L. Bell, Liang, T., G.A. Deehan, Bell, R. L., Z.A. Rodd   +16 more
core   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit

Basic and Clinical Neuroscience, 2015
Introduction: The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-HT) system on cognitive and non-cognitive behaviors.
Mohammad Nasehi
doaj