Results 41 to 50 of about 51,688 (341)

Hypoglossal and phrenic responses to cholinergic agents applied to ventral medullary surface

, 1984
Application of cholinergic agents on the ventrolateral surface of the medulla in areas in which the “central chemoreceptors” are believed to be located stimulates breathing. It is also known that cranial nerves, such as the hypoglossal, have respiratory
N. S. Cherniack, J. Mitra, M. A. Haxhiu, E. van Lunteren, E. N. Bruce   +4 more
core   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Chemoreactom analysis of cytidyldiphosphocholine indicates synergistic combinations of neuroprotective agents

Неврология, нейропсихиатрия, психосоматика, 2021
Objective: to establish the molecular mechanisms of interaction of cytidine-diphosphocholine choline (CDP-choline) with other agents used to treat chronic cerebral ischemia (CCI) to increase the effectiveness of the therapy..Material and methods.
I. Yu. Torshin, O. A. Gromova, L. A. Mayorova, T. R. Grishina, L. E. Fedotova, A. N. Gromov, I. S. Sardaryan   +6 more
doaj   +1 more source

Effects of adrenergic and cholinergic blocking agents on hypothalamic mechanisms

, 1962
Double-walled cannulas, allowing repeated stimulation of the same site in unrestrained animals with crystalline chemicals, were implanted stereotaxically into the hypothalami of 14 albino rats. Histological verification of the intended placements showed
Sebastian P. Grossman
core   +1 more source

Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

BMEMat, EarlyView.
This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.
Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang   +9 more
wiley   +1 more source

Synthesis, Docking and Acetylcholinesterase Inhibitory Evaluation of 1,3,4-Thiadiazole Derivatives as Potential Anti-Alzheimer Agents [PDF]

Pharmaceutical Sciences
Background: According to the cholinergic hypothesis for Alzheimer’s disease, potentiation of cholinergic neurotransmission is one of the best strategies for combating dementia.
Ahmad Mohammadi-Farani, Milad Takesh, Mahsa Mohammadi, Amin Hosseini, Amin Aliabadi, Alireza Aliabadi   +5 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Alpha7 Nicotinic Acetylcholine Receptors Play a Predominant Role in the Cholinergic Potentiation of N-Methyl-D-Aspartate Evoked Firing Responses of Hippocampal CA1 Pyramidal Cells

Frontiers in Cellular Neuroscience, 2017
The aim of the present study was to identify in vivo electrophysiological correlates of the interaction between cholinergic and glutamatergic neurotransmission underlying memory. Extracellular spike recordings were performed in the hippocampal CA1 region
Zsolt K. Bali, Zsolt K. Bali, Lili V. Nagy, Lili V. Nagy, István Hernádi, István Hernádi   +5 more
doaj   +1 more source

Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies

Molecules, 2020
General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing ...
Maarten Honing, Chris Martini, Monique van Velzen, Marieke Niesters, Albert Dahan, Martijn Boon   +5 more
doaj   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source