Results 21 to 30 of about 51,688 (341)

Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats

Scientific Reports, 2022
Successful cholinergic-noradrenergic pharmacotherapy for obstructive sleep apnea (OSA) is thought to be due to effects at the hypoglossal motor nucleus (HMN). Clinical efficacy varies with muscarinic-receptor (MR) subtype affinities. We hypothesized that
Sepehr Niakani, Hattie Liu, Wen-Ying Liu, Richard L. Horner   +3 more
doaj   +1 more source

Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex [PDF]

, 2011
The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infusion into the ...
Brown, MW, Warburton, E Clea, Endean, E. P. E., Fontaine-Palmer, N. S., Chris J. Tinsley, Endean, Emma P E, Aggleton, John P, Tinsley, CJ, John P. Aggleton, Emma P.E. Endean, Vincent, Maria, Aggleton, John Patrick, Endean, EPE, Maria Vincent, E. Clea Warburton, Nadine S. Fontaine-Palmer, Brown, M. W., Malcolm W. Brown, Tinsley, Chris J, Brown, Malcolm W, Vincent, M., Fontaine-Palmer, NS, Tinsley, C. J., Vincent, M, Fontaine-Palmer, Nadine S, Aggleton, JP, Warburton, EC, Warburton, E. C.   +27 more
core   +1 more source

HYPERURICEMIC EFFECTS OF CHOLINERGIC AGENTS IN RATS

Japanese Journal of Pharmacology, 1982
The hyperuricemic effect of cholinergic agents was studied in rats given potassium oxonate which inhibits urate oxidase and in functionally hepatectomized rats. Acetylcholine slightly increased plasma uric acid in the oxonate-treated animals, and the effect was markedly enhanced by pretreatment with physostigmine.
IWAKI, Kazumi, YONETANI, Yukio
openaire   +2 more sources

Medical and non-medical interventions for post-operative urinary retention prevention: network meta-analysis and risk–benefit analysis

Therapeutic Advances in Urology, 2021
Aims: To assess the efficacy in lowering post-operative urinary retention, urinary tract infection and lower urinary tract symptoms and the incidence of adverse events among 12 interventions and to perform risk–benefit analysis.
Pokket Sirisreetreerux, Rujira Wattanayingcharoenchai, Sasivimol Rattanasiri, Oraluck Pattanaprateep, Pawin Numthavaj, Ammarin Thakkinstian   +5 more
doaj   +1 more source

Delirium due to Scopolamine Patch in a 4-Year-Old Boy

Journal of the Formosan Medical Association, 2011
The scopolamine patch is usually used to reduce postoperative nausea and vomiting associated with anesthesia and/or surgery. It is also commonly used for the prevention of motion sickness.
Yang-Guang Lin, Po-Hon Chen, Fang-Yuan Chang, Li-Te Wu, Kuo-Yu Liao, Tzee-Chung Wu   +5 more
doaj   +1 more source

Cholinergic mechanisms in depression [PDF]

, 1986
Evidence supporting a cholinergic hypothesis of depression is presented. First, cholinergic overdrive produces behavioral, neuroendocrine, and polysomnographic features of melancholia, and melancholics exhibit state-independent supersensitivity to ...
Dilsaver, Steven C.
core   +1 more source

Brain gamma rhythm and potential treatment of neurodegenerative disease

Journal of Neurorestoratology, 2020
In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz),
Jianhua Zhao, Ailin Du, Chengbiao Lu
doaj   +1 more source

(-)-Phenserine attenuates soman-induced neuropathology. [PDF]

PLoS ONE, 2014
Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marini   +11 more
doaj   +1 more source

Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus

Frontiers in Medicine, 2021
There is a critical need for safe treatment options to control inflammation in patients with systemic lupus erythematosus (SLE) since the inflammation contributes to morbidity and mortality in advanced disease.
Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, William R. Kem, Victor V. Uteshev, Keisa W. Mathis   +5 more
doaj   +1 more source

THE NATURE OF ACETYLCHOLINE RECEPTOR [PDF]

Acta Medica Iranica, 1983
The present work with consideratlon to the autoradiographic pictures, suggests that cholinergic receptors are located at the gate of a channel originating from synaptic cleft coming to lie within the muscle fibre. AChE molecules stand at the gate of this
M.E. TASHAYOD
doaj   +1 more source