Results 1 to 10 of about 51,688 (341)

Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives [PDF]

Frontiers in Molecular Biosciences
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim, Mohamed M. Ibrahim, Mohamed M. Ibrahim, Monica M. Jablonski, Monica M. Jablonski   +4 more
doaj   +4 more sources

Central Cholinergic Nervous System and Cholinergic Agents [PDF]

Acta Medica, 1998
Central cholinergic nervous system play important role in many physiological and behavioral functions in humans. The activity of the cholinergic nervous system depends upon the production and fate of acetylcholine and all compounds influenced its ...
Jiří Patočka
doaj   +3 more sources

Common Neuroanatomical Substrate of Cholinergic Pathways and Language-Related Brain Regions as an Explanatory Framework for Evaluating the Efficacy of Cholinergic Pharmacotherapy in Post-Stroke Aphasia: A Review

Brain Sciences, 2022
Despite the relative scarcity of studies focusing on pharmacotherapy in aphasia, there is evidence in the literature indicating that remediation of language disorders via pharmaceutical agents could be a promising aphasia treatment option.
Marina Katsari, Georgia Angelopoulou, Nikolaos Laskaris, Constantin Potagas, Dimitrios Kasselimis   +4 more
doaj   +2 more sources

Severe organophosphate intoxication without classic cholinergic signs: A case report and updated literature review [PDF]

Science Progress
Organophosphate compounds such as dichlorvos, a widely used pesticide, account for a substantial proportion of acute poisonings globally. These agents irreversibly inhibit acetylcholinesterase, leading to cholinergic overstimulation.
Ulkar Naghizade, Victor Sabo, Niels Renfer, Stephan Schmid, Martina Müller, Tobias Schilling   +5 more
doaj   +2 more sources

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Frontiers in Cellular Neuroscience, 2020
Background: Extracellular ATP is a powerful trigger of neuroinflammation by activating immune cells via P2X7 receptors. Acetylcholine and nicotinic agonists inhibit ATP-triggered proinflammatory cytokines via the so-called “cholinergic anti-inflammatory ...
Dilyara Nurkhametova, Dilyara Nurkhametova, Andrei Siniavin, Maria Streltsova, Denis Kudryavtsev, Igor Kudryavtsev, Igor Kudryavtsev, Raisa Giniatullina, Victor Tsetlin, Tarja Malm, Rashid Giniatullin, Rashid Giniatullin   +11 more
doaj   +2 more sources

Screening for Copy Number Variations of the 15q13.3 Hotspot in CHRNA7 Gene and Expression in Patients with Migraines

Current Issues in Molecular Biology, 2021
Background: a migraine is a neurological disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated. We investigated the effects of the CNV and gene expression at the location 15q13.3 in the Cholinergic Receptor ...
Mehmet Fatih Özaltun, Sırma Geyik, Şenay Görücü Yılmaz   +2 more
doaj   +1 more source

Prediction of chemical warfare agents based on cholinergic array type meta-predictors

Scientific Reports, 2022
Molecular insights into chemical safety are very important for sustainable development as well as risk assessment. This study considers how to manage future upcoming harmful agents, especially potentially cholinergic chemical warfare agents (CWAs).
Surendra Kumar, Chandni Kumari, Sangjin Ahn, Hyoungrae Kim, Mi-hyun Kim   +4 more
doaj   +1 more source

Intravenous and Non-invasive Drug Delivery to the Mouse Basal Forebrain Using MRI-guided Focused Ultrasound

Bio-Protocol, 2021
Basal forebrain cholinergic neurons (BFCNs) regulate circuit dynamics underlying cognitive processing, including attention, memory, and cognitive flexibility.
Kristiana Xhima, Dallan McMahon, Edward Ntiri, Maged Goubran, Kullervo Hynynen, Isabelle Aubert   +5 more
doaj   +1 more source

Hydro-alcoholic extract of Matricaria recutita exhibited dual anti-spasmodic effect via modulation of Ca2+ channels, NO and PKA2-kinase pathway in rabbit jejunum [PDF]

Avicenna Journal of Phytomedicine, 2017
Objective: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M.
Hamidreza yazdi, Akhtar Seifi, Shima Changizi, Vahid Khori, Fatemeh Hossini, Ali Davarian, Yahya Jand, Ayesheh Enayati, Masumeh Mazandarani, Fateme Nanvabashi   +9 more
doaj   +1 more source

Pathophysiology, Therapeutic Targets, and Future Therapeutic Alternatives in COPD: Focus on the Importance of the Cholinergic System

Biomolecules, 2023
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airway limitation and changes in airway structure. It has a high global burden of mortality and morbidity.
Felisbela Gomes, Shih-Lung Cheng
doaj   +1 more source