Results 181 to 190 of about 29,186 (237)

Cholinergic antagonists and REM sleep generation

Brain Research, 1991
In this study we extended our observations on the role of M1 and M2 muscarinic receptors in mediating the cholinergic induction of REM sleep. Cats were chronically implanted with sleep recording electrodes and microinjections of Ringer's or muscarinic antagonists followed by the relatively specific M2 muscarinic agonist, cis-methyl-dioxolane (cisdioxo),
J, Velazquez-Moctezuma, M, Shalauta, J C, Gillin, P J, Shiromani   +3 more
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[Effects of cholinergic antagonists in stress].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2007
Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer.
G I, Nezhinskaia, N A, Losev, N S, Sapronov   +2 more
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Morphine Withdrawal Syndrome Responses to Cholinergic Antagonists and to a Partial Cholinergic Agonist

Nature, 1973
MORPHINE impairs the release of acetylcholine (ACh) at muscarinic and nicotinic sites in the periphery1–3, and within the brain4–8. Paton9 suggested that morphine's ability to impair ACh release might be the origin of the morphine withdrawal reaction. He proposed that ACh could accumulate within cholinergic terminals during habituation to the narcotic ...
C, Pinsky, R C, Frederickson, A J, Vazquez   +2 more
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The effect of cholinergic antagonists on a central response to nicotine

Experientia, 1982
Mecamylamine and hexamethonium antagonize the prostration response of rats to centrally-administered nicotine; decamethonium and d-tubocurarine are less effective. physostigmine does not elicit the response. Nicotine's central cholinergic effect thus may contribute to but does not fully account for its action.
L S, Schwab, M F, Kritzer
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Aryldiazonium Salts as Antagonists at Cholinergic Muscarinic Receptors

Canadian Journal of Physiology and Pharmacology, 1974
A series of aryldiazonium salts were synthesized and tested for inhibitory activity on the longitudinal muscle of the guinea pig ileum. The most potent member of the series, benzenediazonium fluoborate (BDF) (at 10−4 M with incubation for 5 min), produced a dose ratio of 600 for acetylcholine (Ach), 58 for cis-2-methyl-4-trimethylammonium methyl-1,3 ...
D H, Ross, D J, Triggle
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Methylatropine blocks the central effects of cholinergic antagonists

Behavioural Pharmacology, 1994
These studies were conducted in order to establish the dose dependency and relative peripheral versus central activity of four prototypical cholinergic antagonists on the rodent passive avoidance response, a widely used animal model of retention.
R.D., Smith, M.E., Grzelak, V.L., Coffin
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Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation

Psychopharmacologia, 1963
1. The anticholinergic activity of amitriptyline and a new antidepressant, nortriptyline, which is a secondary amine related to amitriptyline, were compared on guinea pig ileum and salivation of dogs. Both are active anticholinergic agents, but somewhat atypical, by these tests.
R C, RATHBUN, I H, SLATER
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Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome

Psychopharmacology, 1976
The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both 'wet-dog' like body shakes and aggression but it increased diarrhea and weight loss.
M D, Hynes, G, Gianutsos, H, Lal
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AGONIST‐ANTAGONIST INTERACTION AT THE CHOLINERGIC RECEPTOR OF DENERVATED DIAPHRAGM

Australian Journal of Experimental Biology and Medical Science, 1972
SummaryA study has been made of the cholinergic receptor induced by chronic denervation in the rat diaphragm. The agonists acetylcholine, carbachol and tetramethylammonium produced a dose‐dependent contraction of the denervated diaphragm. These agonists also brought about a graded depolarization of the muscle cells.
S E, Freeman, R J, Turner
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Cholinergic agonists and antagonists

1983
This chapter reviews the effects of the parasympathetic nervous system on the physiological properties of the cardiovascular system and the mechanisms by which these effects are produced. In the context of this background, the cardiovascular effects of agents that augment and antagonize parasympathetic nervous system activity will be discussed.
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