Results 241 to 250 of about 31,317 (345)

Evaluation of the Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibitory Potential of Salvia heldreichiana Within the Framework of Molecular Docking and CAVER Tunnel Analysis

open access: yesChemistryOpen, Volume 15, Issue 6, June 2026.
Methanolic extract of Salvia heldreichiana is characterized by HPLC and GC–MS analyses and evaluated for antioxidant and anti‐Alzheimer activities. Major phenolic compounds are identified, while molecular docking analysis supports the interaction of bioactive constituents with target enzymes, highlighting the therapeutic potential of S.
Erdi Can Aytar   +5 more
wiley   +1 more source

Clozapine‐induced diarrhea: A case report and mechanistic overview

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Clozapine is an atypical antipsychotic that is highly effective in managing treatment‐resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well‐
Shahab Dastmardi, Soha Namazi
wiley   +1 more source

Beyond dopamine: Broader neuromodulatory contributions in sign- and goal-tracking. [PDF]

open access: yesPsychopharmacology (Berl)
Datta A   +4 more
europepmc   +1 more source

The importance of longitudinal evaluation using DAT‐SPECT in organophosphate‐induced toxic parkinsonism

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao   +6 more
wiley   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan   +3 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto   +7 more
wiley   +1 more source

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