Results 181 to 190 of about 1,448,122 (321)
A metabolic profile associated with high levels of the nicotine metabolite cotinine was measured from human postmortem frontal cortex and cerebrospinal fluid samples using non‐targeted metabolomics. Key findings were significantly higher levels of 1‐methylhistamine and N‐acetylputrescine, and lower levels of aspartic acid, 3‐methylhistidine and taurine
Wadzanai Masvosva+8 more
wiley +1 more source
Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons
In brains of Alzheimer's disease (AD) patients, expression of the neuropeptide galanin is significantly upregulated and galanin-immunoreactive fibers hypertrophy and hyperinnervate cholinergic neurons of the basal forebrain.
Xiling Ding+3 more
doaj
Galanin Fiber Hyperinnervation Preserves Neuroprotective Gene Expression in Cholinergic Basal Forebrain Neurons in Alzheimer's Disease [PDF]
Scott Counts+4 more
openalex +1 more source
Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper
ABSTRACT Exercise is an important treatment for people with asthma and should be considered alongside pharmacological therapy when developing personalised asthma management plans. Despite this, there remains limited guidance concerning the practicalities of asthma‐specific exercise prescription.
Oliver J. Price+13 more
wiley +1 more source
Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa
Our results reveal the similarities and differences in the input projections to the two types of GABAergic neurons in the globus pallidus externa (GPe) and lay the neuroanatomic groundwork for further studies to explore the critical physiological functions of GPe.
Ming‐feng Ma+8 more
wiley +1 more source
The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley +1 more source
Changes in the cholinergic system of rat sciatic nerve and skeletal muscle following suspension induced disuse [PDF]
Muscle disused induced changes in the cholinergic system of sciatic nerve, slow twitch soleus (SOL) and fast twitch extensor digitorum longus (EDL) muscle were studied in rats. Rats with hindlimbs suspended for 2 to 3 weeks showed marked elevation in the
Dettbarn, W. D.+2 more
core +1 more source
Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy
ABSTRACT Background Early severe autonomic failure (AF) in multiple system atrophy (MSA) is a risk factor for poor survival. Postmortem studies suggested that AF is related to the degeneration of preganglionic autonomic neurons of the brainstem and spinal cord. Objectives Characterize cerebral alterations on brain imaging associated with cardiovascular
Claire Georges+9 more
wiley +1 more source