Results 71 to 80 of about 1,448,122 (321)

Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

Neurobiology of Disease, 2000
Several lines of evidence implicate a cholinergic deficit in Alzheimer's disease (AD). Transgenic mice that overexpress clinical mutants of the human amyloid precursor protein (APP) have been generated that recapitulate many aspects of AD.
Francisca C. Bronfman, Dieder Moechars, Fred Van Leuven   +2 more
doaj  

Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses

Frontiers in Systems Neuroscience, 2014
The organ of Corti, the mammalian sensory epithelium of the inner ear, has two types of mechanoreceptor cells, inner hair cells (IHCs) and outer hair cells (OHCs).
Eleonora eKatz, Eleonora eKatz, Ana Belen eElgoyhen, Ana Belen eElgoyhen   +3 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +2 more sources

Axonal profiling of the common fibular nerve and its branches: Their functional composition and clinical implications

Clinical Anatomy, EarlyView.
Abstract The articular branch (Arb) from the common fibular nerve (CFN) plays a pivotal role in procedures such as genicular nerve blocks since it extensively innervates the anterolateral knee joint. It remains unclear whether the Arb can be classified as purely sensory, and understanding its axonal composition is critical to prevent muscle weakness ...
Taeyeon Kim, Tae‐Hyeon Cho, Shin Hyung Kim, Hun‐Mu Yang   +3 more
wiley   +1 more source

Septo-Hippocampo-Septal Loop and Memory Formation

Basic and Clinical Neuroscience, 2013
Cholinergic and GABAergic fibers in the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven in learning and memory.
Fatemeh Khakpai, Mohammad Nasehi, Ali Haeri-Rohani, Akram Eidi, Mohammad Reza Zarrindast   +4 more
doaj  

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex

Journal of Neuroscience, 2020
ACh is a signaling molecule in the mammalian CNS, with well-documented influence over cognition and behavior. However, the nature of cholinergic signaling in the brain remains controversial, with ongoing debates focused on the spatial and temporal ...
A. Disney, M. Higley
semanticscholar   +1 more source

Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: Toward clinical applications [PDF]

, 2016
Objectives: The objective was to review the literature on diffusion tensor imaging as well as resting-state functional magnetic resonance imaging and electroencephalography (EEG) to unveil neuroanatomical and neurophysiological substrates of Alzheimer ...
BABILONI, CLAUDIO, Dyrba, Martin, Grothe, Michel J., Sepulcre, Jorge, Sorg, Christian, Teipel, Stefan, Zhou, Juan   +6 more
core   +1 more source

Selective attenuation of Ether-a-go-go related K+ currents by endogenous acetylcholine reduces spike-frequency adaptation and network correlation

eLife, 2019
Most neurons do not simply convert inputs into firing rates. Instead, moment-to-moment firing rates reflect interactions between synaptic inputs and intrinsic currents.
Edward D Cui, Ben W Strowbridge
doaj   +1 more source