New Insights Into Cholinergic Neuron Diversity [PDF]
Frontiers in Molecular Neuroscience, 2019 Cholinergic neurons comprise a small population of cells in the striatum but have fundamental roles in fine tuning brain function, and in the etiology of neurological and psychiatric disorders such as Parkinson’s disease (PD) or schizophrenia.
Noorya Yasmin Ahmed +2 more
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Striatal CDK5 Regulates Cholinergic Neuron Activation and Dyskinesia-like Behaviors through BK Channels [PDF]
Research, 2023 Disturbance of the cholinergic system plays a crucial role in the pathological progression of neurological diseases that cause dyskinesia-like behaviors. However, the molecular mechanisms underlying this disturbance remain elusive.
Chu Tong +15 more
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Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype [PDF]
Frontiers in Molecular Neuroscience, 2022 Lipopolysaccharide (LPS) and high-mobility group box 1 (HMGB1) are Toll-like receptor (TLR4) agonists that activate proinflammatory neuroimmune signaling linked to loss of basal forebrain cholinergic neurons (BFCNs) and cognitive deficits.
Fulton T. Crews +3 more
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Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice [PDF]
Neurobiology of Disease, 2021 Dystonia is a neurological movement disorder characterized by sustained or intermittent muscle contractions, repetitive movement, and sometimes abnormal postures.
Yuning Liu +11 more
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Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp [PDF]
Animal Cells and Systems, 2019 A decrease in the activity of choline acetyltransferase, the enzyme responsible for acetylcholine synthesis in the cholinergic neurons cause neurological disorders involving a decline in cognitive abilities, such as Alzheimer’s disease.
Young-Hoon Kang +9 more
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Human umbilical cord mesenchymal stem cells express cholinergic neuron markers during co-culture with amniotic membrane cells and retinoic acid induction. [PDF]
Med J Islam Repub Iran, 2021 Kouchakian MR +7 more
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Frontiers in Neuroscience, 2021 Conserved transcription factors termed “terminal selectors” regulate neuronal sub-type specification and differentiation through combinatorial transcriptional regulation of terminal differentiation genes.
Sydney Popsuj, Alberto Stolfi
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The dopamine neuron synaptic map in the striatum
Cell Reports, 2023 Summary: Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic actions capable of conveying the temporal information in dopamine ...
Nao Chuhma, Soo Jung Oh, Stephen Rayport
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Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin. [PDF]
PLoS ONE, 2018 Basal forebrain cholinergic neurons mature in adolescence coinciding with development of adult cognitive function. Preclinical studies using the rodent model of adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-days on/2-days off from postnatal day
Ryan P Vetreno, Fulton T Crews
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iScience, 2022 Summary: A model was previously proposed that DA neurons provide SHH ligand to striatal interneurons, which in turn support the survival of DA neurons through the release of trophic factors such as Glial cell-derived neurotrophic factor (GDNF).
Flavia Correa Turcato +4 more
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