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Cholinergic Neuronal Deficits in CADASIL [PDF]
Background and Purpose— Previous evidence from MRI and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Methods—
Iryna Ziabreva+5 more
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Preferential cholinergic excitation of corticopontine neurons [PDF]
Key points Phasic activation of M1 muscarinic receptors generates transient inhibition followed by longer lasting excitation in neocortical pyramidal neurons. Corticopontine neurons in the mouse prefrontal cortex exhibit weaker cholinergic inhibition, but more robust and longer lasting excitation, than neighbouring callosal projection neurons ...
Baker, Arielle L.+2 more
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New Insights Into Cholinergic Neuron Diversity [PDF]
Cholinergic neurons comprise a small population of cells in the striatum but have fundamental roles in fine tuning brain function, and in the etiology of neurological and psychiatric disorders such as Parkinson's disease (PD) or schizophrenia. The process of developmental cell specification underlying neuronal identity and function is an area of great ...
Noorya Yasmin Ahmed+2 more
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Cholinergic Inhibition of Neocortical Pyramidal Neurons [PDF]
Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached recordings from neurons in slices of rat somatosensory cortex, we demonstrate that transient ...
Gulledge, Allan T, Stuart, Gregory J
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The Non-neuronal Cholinergic System
Abstract Acetylcholine (ACh) is a well characterized neurotransmitter occurring throughout the animal kingdom. In addition, both muscarinic and nicotinic ACh receptors have been identified on lymphocytes of various origin, and their stimulation by muscarinic or nicotinic agonists elicits a variety of functional and biochemical effects.
Takeshi Fujii, Koichiro Kawashima
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Regulation of Cholinergic Phenotype in Developing Neurons [PDF]
Specification of neurotransmitter phenotype is critical for neural circuit development and is influenced by intrinsic and extrinsic factors. Recent findings in rat hypothalamus in vitro suggest the role of neurotransmitter glutamate in the regulation of cholinergic phenotype.
Andrei B. Belousov+5 more
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Developmental specification of forebrain cholinergic neurons
Striatal cholinergic interneurons and basal forebrain cholinergic projection neurons, which together comprise the forebrain cholinergic system, regulate attention, memory, reward pathways, and motor activity through the neuromodulation of multiple brain circuits.
Robert Machold, Kathryn C. Allaway
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Cholinergic modulation of single lateral geniculate neurons in the cat [PDF]
Isao Matsuoka, E. F. Domino
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Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons [PDF]
RC Malenka+3 more
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Expression of noradrenergic and cholinergic traits by sympathetic neurons cultured without serum [PDF]
E WOLINSKY, SC Landis, PH Patterson
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