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The cholinergic neuronal phenotype in alzheimer′s disease
Metabolic Brain Disease, 2000The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene.
Brygida Berse, Jan Krzysztof Blusztajn
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Distribution of AChE in cholinergic and non-cholinergic neurons
Brain Research, 1981Intracellular and surface acetylcholinesterase activities were determined for individual cholinergic and non-cholinergic neurons dissected from the central nervous system of the leech. Echothiophate pretreatment was used to inhibit selectively extracellular enzyme.
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Are there cholinergic and non-cholinergic paradoxical sleep-on neurones in the pons?
NeuroReport, 1996Using microiontophoresis on unanesthetized head-restrained cats, we have found two distinct groups of neurones exhibiting tonic discharge specific to paradoxical sleep (PS) (PS-on neurones) in the mesopontine tegmentum, which contains both cholinergic and non-cholinergic neurones.
Kazuya Sakai, Yoshimasa Koyama
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The anatomy of the CNS cholinergic neurons
Trends in Neurosciences, 1984Convincing biochemical and pharmacological evidence of the transmitter role of acetylcholine (ACh) in the CNS has been available for some years, but it is only in recent times that unequivocal tools have been obtained for the demonstration of cellular localization of CNS cholinergic neurons.
A. Claudio Cuello, Michael V. Sofroniew
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Beta-amyloid and cholinergic neurons.
Neurochemical research, 2003It is generally accepted that the crucial events in the pathogeny of Alzheimer's disease (AD) are the increased accumulation of amyloidogenic peptides derived from amyloid precursor protein and the harmful actions of these peptides on neurons, which bring about neurodegeneration. The enhanced beta-amyloid accumulation is known to be caused by mutations
Kasparová J, Dolezal
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The cholinergic system in aging and neuronal degeneration
Behavioural Brain Research, 2011The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic projections to the cerebral cortex and hippocampus. The cholinergic neurons of this complex have been assumed to undergo moderate degenerative changes during aging, resulting in ...
Reinhard Schliebs, Thomas Arendt
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Cholinergic neurons in the rat substantia nigra
Neuroscience Letters, 1986The distribution of choline acetyltransferase (ChAT)-like immunoreactivity (LI), demonstrated according to an avidin-biotin procedure, was evaluated in the substantia nigra (SN) of rats. Although ChAT positivity was considerably less in the nigral neuropil than in the interpeduncular nucleus, it was also higher, particularly in caudal pars reticulata ...
Larry L. Butcher, Elizabeth Gould
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Expression of MEGF10 in cholinergic and glutamatergic neurons
Neuroscience Letters, 2017Multiple-EGF like domains 10 (MEGF10) is the mammalian homologue of Draper, a Drosophila phagocytosis receptor that plays an important role in synapse elimination and cell type-specific recognition. However, the expression and function of MEGF10 in the brain remain to be elucidated.
Hiroto Komano +7 more
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The effect of cobrotoxin on cholinergic neurons in the mouse
Life Sciences, 1992By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent cobrotoxin (CT) and the activity of ...
Ruzhu Chen, Susan E. Robinson
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NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE
The Lancet, 1977Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people.
I.E.I. Williams +6 more
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