Results 51 to 60 of about 141,427 (302)

Paying attention to smell: Cholinergic signaling in the olfactory bulb.

Frontiers in Synaptic Neuroscience, 2014
The tractable, layered architecture of the olfactory bulb (OB), and its function as a relay between odor input and higher cortical processing, makes it an attractive model to study how sensory information is processed at a synaptic and circuit level. The
Rinaldo David D'Souza, Sukumar eVijayaraghavan   +1 more
doaj   +1 more source

Lesions of cholinergic pedunculopontine tegmental nucleus neurons fail to affect cocaine or heroin self-administration or conditioned place preference in rats. [PDF]

PLoS ONE, 2014
Cholinergic input to the ventral tegmental area (VTA) is known to contribute to reward. Although it is known that the pedunculopontine tegmental nucleus (PPTg) provides an important source of excitatory input to the dopamine system, the specific role of ...
Stephan Steidl, Huiling Wang, Roy A Wise
doaj   +1 more source

Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies

Pharmaceuticals, 2023
Neuropathic pain affects about 7–8% of the population, and its management still poses challenges with unmet needs. Over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: mAChR and nAChR)
Edouard Montigné, David Balayssac
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Acetylcholine-treated murine dendritic cells promote inflammatory lung injury [PDF]

, 2019
In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Alcain, Julieta María, Candolfi, Marianela, Geffner, Jorge Raúl, Gori, María Soledad, Jancic, Carolina Cristina, Moreno Ayala, Mariela Alejandra, Salamone, Gabriela Veronica, Vanzulli, Silvia, Vermeulen, Elba Monica   +8 more
core   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats [PDF]

Veterinary Research Forum, 2011
The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic
Esmaeal Tamaddonfard, Amir-Abbas Farshid, Sona Seiednejhad, Asghar Morvaridi   +3 more
doaj  

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study [PDF]

, 2013
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep.
A Alonso, A Khateb, A Serrano, AV Kalinchuk, AV Kalinchuk, AV Kalinchuk, BB Fredholm, BG Frenguelli, BP Klyuch, BP Klyuch, C Romano, C Xu, CF Hohmann, D Curran-Everett, D Lovatt, D Stenberg, DG Van Wylen, E Llaudet, E Murillo-Rodriguez, EA Newman, F Longordo, H McIlwain, HK Wigren, Houdini Ho Tin Wu, I Haulica, ID Manns, J Grivel, JB Mitchell, JC Hoffmann, JP Mothet, JT McKenna, JT Porter, LA Etherington, LI Kiyashchenko, LI Schmitt, LO Alanko, M Ballarin, M Radulovacki, M van den Top, M Wall, MA Greco, MG Lee, MJ Wall, MM Halassa, MM Halassa, MM Thakkar, MO Enkvist, Nicholas Dale, O Pascual, P Franken, P Maquet, R Basheer, R Basheer, R Basheer, R Shigemoto, RH Farkas, RM Virus, Robert Edward Sims, S Palchykova, SR Glaum, SR Ticho, T Porkka-Heiskanen, T Porkka-Heiskanen, T Porkka-Heiskanen, TE Bjorness, TR Minor, TV Dunwiddie, V Parpura, V Ramesh, Valérie Mongrain, VM Sciotti, WE Cullinan, ZL Huang   +72 more
core   +2 more sources

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

Molecular Metabolism, 2017
Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong, Dong Kun Lee, Young-Hwan Jo   +2 more
doaj   +1 more source