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Antidepressants and the Muscarinic Acetylcholine Receptor
Archives of General Psychiatry, 1977Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones.
S H, Snyder, H I, Yamamura
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Constitutively active muscarinic receptors
Life Sciences, 2001Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
T A, Spalding, E S, Burstein
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1984
Muscarinic receptors exist in both peripheral tissues and the central nervous system. Their activation is responsible for all the effects elicited by parasympathetic stimulation in the peripheral organs and modulate ganglionic transmission (Wallis, 1979).
Giancarlo Pepeu, Ileana Marconcini Pepeu
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Muscarinic receptors exist in both peripheral tissues and the central nervous system. Their activation is responsible for all the effects elicited by parasympathetic stimulation in the peripheral organs and modulate ganglionic transmission (Wallis, 1979).
Giancarlo Pepeu, Ileana Marconcini Pepeu
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2002
Abstract The pharmacology of acetylcholine is in many ways a very old subject. The use of antimuscarinic plant extracts as both poisons and therapies can be traced back to ancient times. Thus, Linnaeus gave the systematic name Atropa belladonna to the deadly nightshade, in homage to Atropos of Greek mythology, who cuts the thread of life,
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Abstract The pharmacology of acetylcholine is in many ways a very old subject. The use of antimuscarinic plant extracts as both poisons and therapies can be traced back to ancient times. Thus, Linnaeus gave the systematic name Atropa belladonna to the deadly nightshade, in homage to Atropos of Greek mythology, who cuts the thread of life,
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CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment
This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...Abraham, Fisher, Allan I, Levey
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Muscarinic Receptor Antagonists
Pulmonary Pharmacology & Therapeutics, 1999N, Watson, R M, Eglen
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Axoplasmic transport of muscarinic receptors
Nature, 1980The reality of axoplasmic transport is widely accepted; various neutrotransmitters, enzymes, labelled proteins and peptides are known to move rapidly along the axons of different nerve fibres. In the terminals of sympathetic nerves, noradrenaline release is controlled by various regulatory mechanisms which imply the occurrence of presynaptic receptors.
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