Results 21 to 30 of about 43,677 (218)

Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park, Park-Ne Kim, Seong-Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Antispasmodic Effect of Valeriana pilosa Root Essential Oil and Potential Mechanisms of Action: Ex Vivo and In Silico Studies

Pharmaceutics, 2023
Infusions of Valeriana pilosa are commonly used in Peruvian folk medicine for treating gastrointestinal disorders. This study aimed to investigate the spasmolytic and antispasmodic effects of Valeriana pilosa essential oil (VPEO) on rat ileum.
Roberto O. Ybañez-Julca, Ricardo Pino-Ríos, Iván M. Quispe-Díaz, Daniel Asunción-Alvarez, Edwin E. Acuña-Tarrillo, Elena Mantilla-Rodríguez, Patricia Minchan-Herrera, Marcelo A. Catalán, Liz Zevallos-Escobar, Edison Vásquez-Corales, Osvaldo Yáñez, Wilfredo O. Gutiérrez-Alvarado, Julio Benites   +12 more
doaj   +1 more source

The effects of kindling during pregnancy on long-term potentiation (LTP) induction and M1 muscarinic acetylcholine receptors in male rat offspring

Research in Pharmaceutical Sciences, 2023
Background and purpose: Neonates of pregnant women with epilepsy may compromise normal neurodevelopment and hippocampal morphology. Memory and learning disorders and a decrease in verbal IQ scores are seen in these children later in life. In the previous
Ali Pourmotabbed, Razieh Naghizadeh, Farshad Moradpour, Mozhgan Veisi, Seyed Ershad Nedaei, Fatemeh Zarei, Zahra Salimi   +6 more
doaj   +1 more source

Multitargeting nature of muscarinic orthosteric agonists and antagonists

Frontiers in Physiology, 2022
Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
doaj   +1 more source

Muscarinic Receptor Binding of the Novel Radioligand, [3H]Imidafenacin in the Human Bladder and Parotid Gland

Journal of Pharmacological Sciences, 2014
.: The aim of the current study was to demonstrate highly specific and direct binding activity of tritium ([3H])-labeled imidafenacin for labeling muscarinic receptors in human bladder and parotid gland.
Akira Yoshida, Shiori Kuraoka, Yoshihiko Ito, Takashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda, Keisuke Masuyama, Isao Araki, Shizuo Yamada   +10 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle

Respiratory Research, 2010
Background Acetylcholine, the primary parasympathetic neurotransmitter in the airways, plays an important role in bronchoconstriction and mucus production.
Zuyderduyn Suzanne, Hiemstra Pieter S, Rieks Daniëlle, Nanninga Janke E, Kolahian Saeed, Oenema Tjitske A, Halayko Andrew J, Meurs Herman, Gosens Reinoud   +8 more
doaj   +1 more source

Functional characterization of three G protein-coupled acetylcholine receptors in parasitic nematode Trichinella spiralis

International Journal for Parasitology: Drugs and Drug Resistance, 2023
The physiological significance of metabotropic acetylcholine receptors in parasitic nematodes remains largely unexplored. Here, three different Trichinella spiralis G protein-coupled acetylcholine receptors (TsGAR-1, -2, and -3) were identified in the ...
Cáinà Nìng, Aurélie Heckmann, Lourdes Mateos-Hernández, Grégory Karadjian, Ladislav Šimo   +4 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source