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A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia [PDF]
Frontiers in Cellular Neuroscience, 2023 Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the ...
Brian Dean +6 more
doaj +2 more sources
Agonist-selective activation of individual G-proteins by muscarinic receptors [PDF]
Scientific ReportsSelective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well.
Dominik Nelic +8 more
doaj +2 more sources
Distribution of Muscarinic Acethylcholine Receptors and Related Signal [PDF]
Türk Biyokimya Dergisi, 2006 Muscarinic receptors are members of G protein coupled receptor family. Molecularcloning studies indicate five intronless genes that encode five muscarinic receptorglycoproteins.
Hülya Cabadak
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Muscarinic Receptors Associated with Cancer. [PDF]
Cancers (Basel), 2022 SIMPLE SUMMARY: Recently, cancer research has described the presence of the cholinergic machinery, specifically muscarinic receptors, in a wide variety of cancers due to their activation and signaling pathways associated with tumor progression and ...
Calaf GM +4 more
europepmc +2 more sources
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids [PDF]
International Journal of Molecular Sciences, 2022 Eszter Szánti-Pintér +2 more
exaly +2 more sources
Are Voltage Sensors Really Embedded in Muscarinic Receptors? [PDF]
Int J Mol Sci, 2023 Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor ...
Cohen-Armon M.
europepmc +2 more sources
Frontiers in Neural Circuits, 2021 Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan +2 more
doaj +1 more source
Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]
International Neurourology Journal, 2012 The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada +3 more
doaj +1 more source
Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates. [PDF]
PLoS ONE, 2015 Cholinergic, muscarinic receptor agonists exhibit functional dopamine antagonism and muscarinic receptors have been suggested as possible future targets for the treatment of schizophrenia and drug abuse. The muscarinic ligand (5R,6R)-6-(3-butylthio-1,2,5-
Maibritt B Andersen +6 more
doaj +1 more source
PLoS ONE, 2020 Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic therapy ...
Alejandro J. Español +7 more
doaj +2 more sources