Results 41 to 50 of about 52,654 (280)

Brain muscarinic cholinergic receptors in Huntington's disease [PDF]

, 1992
Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects.
Marsden, C. D., Jenner, P., Agid, Y., Lange, Klaus W., Javoy-Agid, F.   +4 more
core   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

The actions of Pasteurella multocida toxin on neuronal cells

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid, Robbins, Jon, Duricki, DA, Surguy, SM, Duricki, Denise A., Duricki, Denise, Lax, AJ, Reilly, JM, Reilly, Joanne, Surguy, Susan, Surguy, Susan M., Reilly, Joanne M., Robbins, J, Lax, Alistair J.   +13 more
core   +1 more source

Allosteric modulators targeting CNS muscarinic receptors [PDF]

, 2018
Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) which are broadly expressed in the central nervous system (CNS) and other tissues in the periphery.
Mohr, K., Andreas Bock, Schrage, R., Ramona Schrage, Klaus Mohr, Bock, A.   +5 more
core   +1 more source

Cholinergic partition cells and lamina X neurons induce a muscarinic-dependent short-term potentiation of commissural glutamatergic inputs in lumbar motoneurons.

Frontiers in Neural Circuits, 2011
Acetylcholine and the activation of muscarinic receptors influence the activity of neural networks generating locomotor behaviour in the mammalian spinal cord.
Sandrine S Bertrand, Jean-René eCazalets   +1 more
doaj   +1 more source

The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]

PLoS ONE, 2011
Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun, Dong-Ling Li, Mei Zhao, Xi He, Xiao-Jiang Yu, Yi Miao, Hao Wang, Jun Ren, Wei-Jin Zang   +8 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors [PDF]

, 2016
Scopolamine is a high affinity muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. 5-HT3 receptor antagonists are used for the same purpose and are structurally related to scopolamine.
Thompson, Andrew J., Lochner, Martin, Thompson, Andrew James   +2 more
core   +1 more source

Assessment of Muscarinic Receptor Subtypes in Human and Rat Lower Urinary Tract by Tissue Segment Binding Assay

Journal of Pharmacological Sciences, 2008
Muscarinic receptors in the human and rat lower urinary tract (urinary bladder detrusor muscle and mucosa, and prostate) were identified by intact tissue segment binding assays with two radioligands, and the effects of prolonged receptor activation in ...
Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Hatsumi Yoshiki, Zakia Sultana Sathi, Hironobu Akino, Osamu Yokoyama, Ikunobu Muramatsu   +8 more
doaj   +1 more source

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 900-911, April 2025.
Central illustration. Abbreviations: ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNi, angiotensin‐receptor‐neprilysin inhibitor; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; CV, cardiovascular; EF, ejection fraction; eGFR, estimated glomerular ...
Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese   +12 more
wiley   +1 more source