Results 171 to 180 of about 2,823,581 (316)

Treating Alzheimer's Disease With Cholinesterase Inhibitors: What Have We Learned So Far? [PDF]

, 2002
Howard Feldman
openalex   +1 more source

From Herbal Tea to Science: Phytochemical and Biological Investigation of Ajuga chamaepitys subsp. chia (Lamiaceae) With Molecular Docking Analysis

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The present study comprehensively investigates the phytochemical profile, biological activities, and molecular docking interactions of Ajuga chamaepitys subsp. chia. Methanolic extracts exhibited notable antioxidant, antidiabetic, and anticholinesterase activities, while germacrene D demonstrated strong multitarget binding affinities in silico.
Bilge Aydın, Amine Sena Aydın, Ömer Çeçen, Hafize Yuca, Gülnur Ekşi Bona, Betül Demirci, Mehmet Bona, Songul Karakaya   +7 more
wiley   +1 more source

A highly sensitive assay method to determine basal acetylcholine level in the microdialysis of rat frontal cortex using a horse-radish peroxidaseosmium redox polymer electrode and HPLC with pre-enzyme reactor without use of cholinesterase inhibitor.

, 1996
Takeshi Kato, Jian Kai Liu, Katsunobu Yamamoto, Peter G. Osborne, Osamu Niwa   +4 more
openalex   +1 more source

First Insights Into the LC‐HRMS Profiling and Biological Activities of Crocus graveolens

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study reports the first comprehensive analysis of Crocus graveolens Boiss. & Reut. using LC‐HRMS, identifying 33 secondary metabolites, with rutin as the major compound (162.808 ± 4.5 μg/g extract). The extract showed moderate antioxidant activity and effectively inhibited acetylcholinesterase (30.88% ± 1.51%) and butyrylcholinesterase (61.22% ± 0.
Ezgi Ersoy, Mehmet Boğa, Alevcan Kaplan, Emel Mataracı Kara, Serpil Demirci Kayıran, Esra Eroğlu Özkan   +5 more
wiley   +1 more source

Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study. [PDF]

Front Pharmacol, 2023
Zhang N, Gan L, Xiang G, Xu J, Jiang T, Li Y, Wu Y, Ni R, Liu Y.   +8 more
europepmc   +1 more source

Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors [PDF]

, 2003
P Bordier
openalex   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, Volume 25, Issue 15, Page 42-49, August 2025.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine. [PDF]

Dement Neurocogn Disord
Kim Y, Kang DW, Kim GH, Kim KW, Kim HJ, Na S, Park KH, Park YH, Byeon G, Suh J, Shin JH, Shim Y, Yang Y, Um YH, Oh SI, Wang SM, Yoon B, Lee SM, Lee J, San Lee J, Lim JS, Jung YH, Chin J, Jang H, Choi M, Hong YJ, Rhee HY, Jang JW, Korean Dementia Association.   +28 more
europepmc   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer's disease [PDF]

, 2003
Debomoy K. Lahiri, Martin R. Farlow
openalex   +1 more source