Results 1 to 10 of about 17,327 (143)

Nanostructured Lipid Carriers Loaded with Donepezil for Nose-to-Brain Targeting [PDF]

Pharmaceutics
Background/Objectives: The oral administration of donepezil has been shown to have common side effects due to systemic drug delivery, with fluctuations in blood and brain donepezil concentrations.
Isabelly Fernanda Ferraz de Souza, Rodrigo Vicentino Placido, Maria Júlia Placido, Letícia Carvalho Rocha, Rudy Bonfilio, Vanessa Bergamin Boralli, André Luís Morais Ruela, Gislaine Ribeiro Pereira   +7 more
doaj   +2 more sources

Switching from Oral Cholinesterase Inhibitors to a Transdermal Donepezil Patch Attenuated Gastrointestinal Symptoms and Allowed Treatment Continuation in Three Patients with Alzheimer’s Disease in Clinical Settings [PDF]

Brain Sciences
Background: Cholinesterase inhibitors (ChEIs) are commonly prescribed for the treatment of Alzheimer’s disease (AD) and achieve long-term benefits for cognition and survival in real-world settings.
Yumiko Motoi, Nobuo Sanjo
doaj   +2 more sources

Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys

Biological Psychiatry Global Open Science, 2023
Background: Donepezil exerts pro-cognitive effects by nonselectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive flexibility are the prefrontal ...
Seyed A. Hassani, Sofia Lendor, Adam Neumann, Kanchan Sinha Roy, Kianoush Banaie Boroujeni, Kari L. Hoffman, Janusz Pawliszyn, Thilo Womelsdorf   +7 more
doaj   +1 more source

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice

Molecular Brain, 2022
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear.
Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon, Hyang-Sook Hoe   +11 more
doaj   +1 more source

Impact of Plasma Donepezil Concentration on Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders Extra, 2021
Background/Aims: The behavioral and psychological symptoms of dementia (BPSD) detract from the quality of life of not only dementia patients but also their family members and caregivers.
Yoshiyuki Kagawa, Yoshiaki Yamamoto, Ayami Ueno, Kengo Inomata, Mayu Tezuka, Takashi Osawa, Yasuharu Yazawa, Toshio Maeda, Tomokazu Obi   +8 more
doaj   +1 more source

Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease

Journal of the Formosan Medical Association, 2022
Background/purpose: Donepezil was approved for the treatment of Alzheimer's disease (AD) but causes variable therapeutic responses. Thus, identifying specific genetic polymorphisms, which can predict a therapeutic response to donepezil, would enable a ...
Ping-Song Chou, Ling-Chun Huang, Tzyh-Chyuan Hour, Chen-Wen Yen, Yuan-Han Yang   +4 more
doaj   +1 more source

Pain with Donepezil [PDF]

Age and Ageing, 2006
An 85-year-old lady with a 4-year history of Alzheimer's dementia was started on a dose of 5 mg of Donepezil. Improvements were noted in her overall mental state with an associated reduction in the level of carer stress but with mild and transient subjective gastrointestinal complaints. Therefore, the dose was cautiously increased to 10 mg.
Chetan Bangra, Kuloor, Ananth, Puranik
openaire   +2 more sources

Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice

Journal of Pharmacological Sciences, 2022
Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy.
Kouichi Yamamoto, Yuhki Sato, Keisuke Hagihara, Kyosuke Kirikihira, Akito Jotaki, Ayana Michihara, Yumi Miyake   +6 more
doaj   +1 more source

Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats

Journal of Integrative Neuroscience, 2023
Purpose: Opioid use disorder is a significant global problem. Chronic heroin use is associated with impairment of cognitive function and conscious control ability.
Disen Mei, Fangmin Wang, Bo Yuan, Miaojun Lai, Yiying Zhou, Wei Cui, Huifen Liu, Wenhua Zhou   +7 more
doaj   +1 more source

Donepezil-associated survival benefits among Alzheimer’s disease patients are retained but not enhanced during COVID-19 infections

Therapeutic Advances in Infectious Disease, 2023
Background and Aim: Donepezil is a front-line treatment for Alzheimer’s disease. Donepezil treatment is associated with decreased risk of all-cause mortality. Specific protection is observed in pneumonia and cardiovascular disease.
Elizabeth A. Edmiston, Taissa A. Bej, Brigid Wilson, Robin L. P. Jump, Joy A. Phillips   +4 more
doaj   +1 more source