Results 1 to 10 of about 17,393 (175)

Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice. [PDF]

PLoS ONE, 2011
BACKGROUND: We have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (MI).
Mikihiko Arikawa, Yoshihiko Kakinuma, Takemi Handa, Fumiyasu Yamasaki, Takayuki Sato   +4 more
doaj   +1 more source

The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherapies for Treating Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: Systematic Review and Meta-Analysis

Dementia and Geriatric Cognitive Disorders Extra, 2011
Background/Aims: Behavioural and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared ...
I.A. Lockhart, M.E. Orme, S.A. Mitchell
doaj   +1 more source

Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride: P300 event related potential

Neural Regeneration Research, 2016
Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days), or combined with acupuncture at Shenting (DU24), Tianzhu ...
Qiang Liu, Xiu-juan Wang, Zhe-cheng Zhang, Rong Xue, Ping Li, Bo Li   +5 more
doaj   +1 more source

Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients

Clinical Interventions in Aging, 2018
Nan Zhang,1,2 Marc L Gordon3,4 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 2Department of Neurology and Neurosurgery, Tianjin Medical University ...
Zhang N, Gordon ML
doaj  

Obsessive–compulsive disorder induced by donepezil in a patient with Alzheimer's disease

PCN Reports
Background Donepezil, an acetylcholinesterase inhibitor commonly used to treat Alzheimer's disease (AD), is generally well tolerated. There have been no previous reports on donepezil‐induced obsessive–compulsive disorder (OCD).
Kohei Echizen, Daisuke Hirose
doaj   +1 more source

Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil

康复学报, 2015
Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke.Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group (n=19) and control group (n=18).
Xi CHENG, Jinghui LAI, Zhifeng WANG, Yanling GAO, Xiaofeng CHEN, Ling LIN   +5 more
doaj  

Evaluation of the antioxidant activity of donepezil - in vitro study

National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Donepezil is a cerebroselective anticholinesterase which is majorly used for memory enhancement in Alzheimer’s disease (AD). The main action is through increasing central cholinergic neurotransmission but also indicated that it protects ...
Vinay Munishamappa, Seethalakshmi, Vijayakumar A E, Rajathilagam T   +3 more
doaj   +1 more source

Donepezil Combined with Natural Hirudin Improves the Clinical Symptoms of Patients with Mild-to-Moderate Alzheimer's Disease: A 20-Week Open-Label Pilot Study

International Journal of Medical Sciences, 2012
Aim: To evaluate the efficacy and safety of donepezil plus natural hirudin in patients with mild-to-moderate Alzheimer's Disease. Methods: In the 20-week, randomized, open-label and controlled study, 84 patients received either donepezil (5 mg/day for ...
De-qiang Li, Yu-ping Zhou, Han Yang
doaj  

Healthcare related costs associated with donepezil use in patients with very mild dementia due to Alzheimer's disease: A retrospective observational study

Journal of Alzheimer's Disease Reports
Background The cost-effectiveness of Donepezil in mild to severe Alzheimer's disease (AD) has been widely studied, but research on very mild dementia (VMD) remains limited.
Sun-Wung Hsieh, Chen-Yang Hsiao, Yuan-Han Yang, Hui-Min Hsieh   +3 more
doaj   +1 more source

Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the CA1 Hippocampus in Rat Model of Alzheimer\'s Disease

Basic and Clinical Neuroscience, 2019
Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region ...
Azade Eskandary, Ahmad Ali Moazedi, Hossein Najaph Zade, Mohamad Reza Akhond   +3 more
doaj