Results 31 to 40 of about 33,915 (216)

A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes [PDF]

, 2008
Peer reviewedPublisher ...
AM Wood, AR Donders, B Winblad, BG Feagan, C Ballard, Craig R Ramsay, D Curran, D Moher, DL Fairclough, EM Hunkeler, G Molenberghs, GL Gadbury, Graeme Maclennan, J Fairbank, JA Blumenthal, JG Wright, Jonathan A Cook, JR Carpenter, JR Korzenik, JR Ware, KJ Thomas, KS Nair, L Petersen, L- Yu, LL Hsieh, M Buszewicz, M Liu, MA Berry, MG Kenward, PM Fayers, R Brooks, RC Petersen, RJ McManus, RJA Little, SA Kaplan, Shona Fielding, SJ Meggitt, T Kennedy   +37 more
core   +4 more sources

Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer’s patients

Frontiers in Neurology
BackgroundGinkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed.ObjectiveWe investigated whether ...
YoungSoon Yang, Min-Seong Koo, Yong Tae Kwak   +2 more
doaj   +1 more source

The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis

Journal of the Formosan Medical Association, 2022
Background: Donepezil had been recognized to have impact on sleep quality in demented patients. However, there was insufficient evidences about the actual effect of donepezil in the sleep architectures.
Cheng-Fang Hsieh, Ping-Tao Tseng, Tien-Yu Chen, Pao-Yen Lin, Yen-Wen Chen, Bo-Lin Ho, Chung-Yao Hsu, Ching-Kuan Liu   +7 more
doaj   +1 more source

Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial [PDF]

, 2017
BACKGROUND/OBJECTIVES: Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to ...
Boustani, Malaz A., Callahan, Christopher M., Campbell, Noll L., Fowler, Nicole, Gao, Sujuan, Hendrie, Hugh C., Li, Lang, Perkins, Anthony J., Skaar, Todd C.   +8 more
core   +1 more source

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Molecules, 2021
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet.
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova   +14 more
doaj   +1 more source

Beneficial effects of pharmacological treatment in post-stroke dynamic aphasia: a behavioural and neuroimaging study [PDF]

, 2018
Introduction : Dynamic Aphasia (DA) is a rare form of language disorder characterized by reduced spontaneous speech with preservation of other language functions.
Beltrán-Corbellini, Álvaro, Berthier-Torres, Marcelo Luis, Davila, Guadalupe, Edelkraut, Lisa-Marie, López-Barroso, Diana, Paredes-Pacheco, José, Reina, Sergio, Roé-Vellvé, Núria, Torres-Prioris, María José   +8 more
core  

Is the relationship among outcome variables shown in randomized trials? [PDF]

, 2015
BACKGROUND: Randomized controlled trials (RCTs) often have more than one primary outcome and frequently have secondary and harm outcomes. Comparison of outcomes between study arms is the primary focus of RCTs, but there are times when the relation ...
Altman, Douglas, Cooper, Richelle, Lopez-OSullivan, Ana, Schriger, David, Wystrach, Carter   +4 more
core   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region

Dementia and Geriatric Cognitive Disorders Extra, 2016
Background: The ‘Asia-Pacific Expert Panel (APEX) for donepezil 23 mg' met in November 2015 to review evidence for the recently approved high dose of donepezil and to provide recommendations to help physicians in Asia make informed clinical decisions ...
Marwan Sabbagh, SeolHeui Han, SangYun Kim, Hae-Ri Na, Jae-Hong Lee, Nagaendran Kandiah, Kammant Phanthumchinda, Chuthamanee Suthisisang, Vorapun Senanarong, Ming-Chyi Pai, Diatri Narilastri, Ajit M. Sowani, Encarnita Ampil, Amitabh Dash   +13 more
doaj   +1 more source

Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy [PDF]

, 2013
Introduction: Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination treatment with memantine added to stable donepezil in ...
Atri, Alireza, Lemming, Ole, Molinuevo, José L, Pulte, Irena, Wilkinson, David, Wirth, Yvonne   +5 more
core   +1 more source