Results 31 to 40 of about 21,434 (231)

Sinus Pause and Cognitive Dysfunction: Diagnostic and Therapeutic Implications. [PDF]

Clin Case Rep
ABSTRACT Bradyarrhythmia‐related cerebral hypoperfusion should be considered in elderly patients presenting with unexplained episodic cognitive decline, particularly when symptoms fluctuate or occur transiently. Prolonged rhythm monitoring may identify potentially treatable arrhythmic causes.
Mohd Zulastri MA, Aseri MA, Syed Sheikh SS, Zainal Abidin I.   +3 more
europepmc   +2 more sources

A Multicentre, Randomised, Open-Label, Prospective Study to Estimate the Add-On Effects Of Memantine as Ebixa® Oral Pump (Solution) on Language in Patients with Moderate to Severe Alzheimer’s Disease Already Receiving Donepezil (ROMEO-AD)

Neurology and Therapy, 2023
Introduction This multicentre, randomised, open-label, and prospective study aimed to evaluate the effectiveness of memantine (memantine solution) on speech function in patients with moderate to severe Alzheimer’s disease (AD) who were already on ...
Hee-Jin Kim, YongSoo Shim, Hyun Jeong Han, Byeong C. Kim, Kee Hyung Park, So Young Moon, Seong Hye Choi, Dong Won Yang, Bora Yoon, Eun-Joo Kim, Jee Hyang Jeong, Seol-Heui Han   +11 more
doaj   +1 more source

Donepezil Multicomponent Systems: Donepezil–Water–Maleic Acid Crystals and More

, 2020
Eight donepezil multicomponent systemssix new multicomponent systems (donepezil–mandelic acid, donepezil–mandelic acid–water, donepezil–water–maleic acid, donepezil–fumaric acid, donepezil–benzenesulfonic acid–water, and donepezil 3.5 hydrate) and two ...
Sung Kwon Kang, Sung Kwon Kang (1669081), Eun Hee Lee, Daeyoung Kim, Daeyoung Kim (531188), Jae Ho Bae (1669093), Jae Ho Bae, Jisun Yeon, Hyun Ji Sun (8524353), Arm Park, Hyun Ji Sun, Jisun Yeon (2618620), Arm Park (8524356), Eun Hee Lee (1669087)   +13 more
core   +1 more source

Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. [PDF]

PLoS ONE, 2017
This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive ...
Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen, Kuei-Ru Chou   +6 more
doaj   +1 more source

Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer’s patients

Frontiers in Neurology
BackgroundGinkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed.ObjectiveWe investigated whether ...
YoungSoon Yang, Min-Seong Koo, Yong Tae Kwak   +2 more
doaj   +1 more source

The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis

Journal of the Formosan Medical Association, 2022
Background: Donepezil had been recognized to have impact on sleep quality in demented patients. However, there was insufficient evidences about the actual effect of donepezil in the sleep architectures.
Cheng-Fang Hsieh, Ping-Tao Tseng, Tien-Yu Chen, Pao-Yen Lin, Yen-Wen Chen, Bo-Lin Ho, Chung-Yao Hsu, Ching-Kuan Liu   +7 more
doaj   +1 more source

Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Molecular Medicine, 2023
Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as ...
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn   +8 more
doaj   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Molecules, 2021
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet.
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova   +14 more
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source