First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation [PDF]
, 2013 : A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C–H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to ...
Karl Kirchner +4 more
core +3 more sources
Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration [PDF]
Nature CommunicationsChiral N-heterocycles such as piperidines and tetrahydroisoquinolines are privileged structural motifs in drug discovery and pharmaceutical industry.
Dazhuang Zhang +3 more
doaj +2 more sources
Synthesis, Antimicrobial Activity and Cytotoxicity of Novel (Piperidin-4-yl)adamantane-1-carboxylate N-Substituted Derivatives [PDF]
MoleculesThe cyclic adamantane framework possesses unique properties such as bulkiness, symmetry, and high lipophilicity. Research aimed at discovering new pharmaceutical agents within the adamantane series continues.
Kaldybay D. Praliyev +13 more
doaj +2 more sources
Search for Antiviral Preparations in Series of New Derivatives of N-Substituted Piperidines [PDF]
MoleculesCyanohydrin synthesis, as the simplest preparative method for introducing a carboxyl group into a piperidine molecule, has been used to obtain potentially biologically active piperidinecarboxylic acids, which have alkyl and arylalkyl radicals at the ...
Gulmira S. Akhmetova +10 more
doaj +2 more sources
PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines [PDF]
Beilstein Journal of Organic Chemistry, 2011 PEG-embedded potassium tribromide ([K+PEG]Br3−) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester.
Sanny Verma, Suman L. Jain, Bir Sain
doaj +2 more sources
Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
doaj +1 more source
Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates
Molecules, 2021 Series of methyl 3- and 5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates were developed and regioselectively synthesized as novel heterocyclic amino acids in their N-Boc protected ester form for achiral and chiral building blocks.
Gita Matulevičiūtė +9 more
doaj +1 more source
CeO2/CuO@N-GQDs@NH2 nanocomposite as a reusable and efficient catalyst for the synthesis of piperidines [PDF]
Nanochemistry Research, 2020 An efficient pseudo six-component synthesis of bis-spiropiperidinesis presented by one-pot condensation of formaldehyde, aromatic amine and dimedone or N,N-dimethyl-barbituric acid using CeO2/CuO@N-GQDs@NH2 nanocomposite at room temperature. The catalyst
Hossein Shahbazi-Alavi +2 more
doaj +1 more source
One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines
Molecules, 2022 Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song +5 more
doaj +1 more source
Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents
Molecules, 2022 The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4 ...
Alexei Lukin +6 more
doaj +1 more source