Results 1 to 10 of about 11,513 (251)
Nature Communications, 2021 1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu +4 more
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Molecules, 2012 An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida +8 more
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A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro
Pharmaceuticals, 2022 There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity
Sonia De Castro +13 more
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Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents
Molecules, 2022 Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore +2 more
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Journal of Pure and Applied Microbiology, 2019 Opportunistic pathogens prevail in the hospital environment, and utensils are the root cause of severe nosocomial infection. These pathogens exhibit high antibiotic resistance due to constant exposure to drug therapy.
Rajendran Venkatasubramani +1 more
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Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title hydrate, C16H23BrN2O·2H2O, the organic molecule features a strong intramolecular O—H...N hydrogen bond. The piperidine ring, in addition, adopts a chair conformation with the exocyclic C—N bond in an equatorial orientation.
Joel T. Mague +4 more
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Nature Communications, 2020 Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon +6 more
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1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 In the crystal structure of the title compound, C17H25N3O2, one-dimensional chains are formed via intermolecular C—H...O hydrogen bonds along the a axis.
Zhe-Qin Wang, Yi Ma
openaire +3 more sources
Molecules, 2013 Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
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Journal of Advanced Research, 2018 Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated.
Suvankar Das +14 more
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