Results 21 to 30 of about 14,777 (274)

Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents

Molecules, 2022
The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4 ...
Alexei Lukin, Mikhail Chudinov, Tatiana Vedekhina, Elizaveta Rogacheva, Lyudmila Kraeva, Olga Bakulina, Mikhail Krasavin   +6 more
doaj   +1 more source

PIPERIDINE : A CORRECTION. [PDF]

The Lancet, 1898
n ...
Tunnicliffe, F. W., Rosenheim, Otto
openaire   +2 more sources

Crystal structure of a tetranuclear CuII complex with an O,N,N′-donor Schiff base ligand: hexa-μ2-acetato-bis(2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino]methyl}phenolato-κ3O,N,N′)tetracopper(II)

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, [Cu4(CH3COO)6(C16H23N2O)2], lies across a twofold rotation axis. The asymmetric unit contains two independent CuII ions. The symmetry-unique terminal CuII ion is O,N,N′-coordinated by a 2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino ...
Guohui Huang, Xiaoxuan Liu
doaj   +1 more source

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

Molecules, 2019
GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

Epidemiological Study of Multidrug Resistant and Efficiency of Piperidine Compounds against Hospital Acquired Opportunistic Pathogens in Tamil Nadu, India

Journal of Pure and Applied Microbiology, 2020
The pathogens attained through nosocomial infection exhibit a higher degree of antibiotic resistance due to constant exposure to drug therapy. There is a need to develop alternate therapeutics for treating these resistant pathogens.
Rajendran Venkatasubramani, Thirumoorthy Viswanathan   +1 more
doaj   +1 more source

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

Frontiers in Chemistry, 2019
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate ...
Alaa Zidan, Alaa Zidan, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm   +5 more
doaj   +1 more source

Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

Nature Communications, 2021
1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu, Xiao-Yuan Cui, Xing-Ping Zeng, Jin-Sheng Yu, Jian Zhou   +4 more
doaj   +1 more source

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

Pharmaceuticals, 2022
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens   +13 more
doaj   +1 more source

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source