Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration [PDF]
Nature CommunicationsChiral N-heterocycles such as piperidines and tetrahydroisoquinolines are privileged structural motifs in drug discovery and pharmaceutical industry.
Dazhuang Zhang +3 more
doaj +2 more sources
One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines
Molecules, 2022 Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song +5 more
doaj +2 more sources
Synthesis, Antimicrobial Activity and Cytotoxicity of Novel (Piperidin-4-yl)adamantane-1-carboxylate N-Substituted Derivatives [PDF]
MoleculesThe cyclic adamantane framework possesses unique properties such as bulkiness, symmetry, and high lipophilicity. Research aimed at discovering new pharmaceutical agents within the adamantane series continues.
Kaldybay D. Praliyev +13 more
doaj +2 more sources
Highly Diastereoselective Arylations of Substituted Piperidines
, 2016 A highly diastereoselective methodology for the preparation of various substituted piperidines via Negishi cross-couplings with (hetero)aryl iodides was developed.
Hendrik Zipse (1265805) +7 more
core +9 more sources
Stereoselective synthesis of piperidines [PDF]
, 2008 EDITED ABSTRACT. This thesis is divided into two parts. The first part describes the production of a small stereodiverse library of 2-substituted piperidines.
Adriaenssens, Louis
core +7 more sources
Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
doaj +1 more source
Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines [PDF]
, 2021 The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally ...
Roger, Whitehead +10 more
core +2 more sources
Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates
Molecules, 2021 Series of methyl 3- and 5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates were developed and regioselectively synthesized as novel heterocyclic amino acids in their N-Boc protected ester form for achiral and chiral building blocks.
Gita Matulevičiūtė +9 more
doaj +1 more source
CeO2/CuO@N-GQDs@NH2 nanocomposite as a reusable and efficient catalyst for the synthesis of piperidines [PDF]
Nanochemistry Research, 2020 An efficient pseudo six-component synthesis of bis-spiropiperidinesis presented by one-pot condensation of formaldehyde, aromatic amine and dimedone or N,N-dimethyl-barbituric acid using CeO2/CuO@N-GQDs@NH2 nanocomposite at room temperature. The catalyst
Hossein Shahbazi-Alavi +2 more
doaj +1 more source
[Co(TPP)]-Catalyzed Formation of Substituted Piperidines [PDF]
, 2019 Radical cyclization via cobalt(III)–carbene radical intermediates is a powerful method for the synthesis of (hetero)cycles. Building on the recently reported synthesis of N-heterocyclic pyrrolidines catalyzed by Co(II) porphyrins, we herein report the ...
Marianne, Lankelma +2 more
core +3 more sources