Results 11 to 20 of about 40,681 (241)

[Co(TPP)]-Catalyzed Formation of Substituted Piperidines [PDF]

Chemistry, 2019
Radical cyclization via cobalt(III)–carbene radical intermediates is a powerful method for the synthesis of (hetero)cycles. Building on the recently reported synthesis of N-heterocyclic pyrrolidines catalyzed by Co(II) porphyrins, we herein report the ...
Marianne, Lankelma, Astrid M., Olivares, Bas, de Bruin   +2 more
core   +3 more sources

Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines

Journal of the American Chemical Society, 2021
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally ...
Roger, Whitehead, Nicholas, Turner, James, Marshall, James, Finnigan, Antonio, Angelastro, Amelia, Gilio, Rachel, Heath, Vanessa, Harawa, Gideon, Grogan, Thomas, Thorpe, Simon, Charnock   +10 more
core   +2 more sources

Synthesis of chiral piperidines from pyridinium salts via rhodium-catalysed transfer hydrogenation [PDF]

Nature Catalysis, 2022
Chiral piperidines are widespread in natural products and drug molecules. However, effective methods for their synthesis from simple starting materials are scarce.
Zhang, Shiyu, Wu, Jianjun, Gunasekar, Ramachandran, Pu, Chunyang, Wu, Xiaofeng, Chen, Zhenyu, Barnard, Jonathan H, Ruan, Jiwu, Xiao, Jianliang   +8 more
core   +2 more sources

Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration [PDF]

Nature Communications
Chiral N-heterocycles such as piperidines and tetrahydroisoquinolines are privileged structural motifs in drug discovery and pharmaceutical industry.
Dazhuang Zhang, He Yang, Qinghai Zhou, Wenjun Tang   +3 more
doaj   +2 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +2 more sources

Synthesis, Antimicrobial Activity and Cytotoxicity of Novel (Piperidin-4-yl)adamantane-1-carboxylate N-Substituted Derivatives [PDF]

Molecules
The cyclic adamantane framework possesses unique properties such as bulkiness, symmetry, and high lipophilicity. Research aimed at discovering new pharmaceutical agents within the adamantane series continues.
Kaldybay D. Praliyev, Gulmira S. Akhmetova, Ulzhalgas B. Issayeva, Samir A. Ross, Manas T. Omyrzakov, Ilya S. Korotetskiy, Ardak B. Jumagaziyeva, Aigul E. Malmakova, Tulegen M. Seilkhanov, Ubaidilla M. Datkhayev, Lyudmila N. Ivanova, Zhanar A. Iskakbayeva, Olzhas T. Seilkhanov, Natalya V. Zubenko   +13 more
doaj   +2 more sources

Search for Antiviral Preparations in Series of New Derivatives of N-Substituted Piperidines [PDF]

Molecules
Cyanohydrin synthesis, as the simplest preparative method for introducing a carboxyl group into a piperidine molecule, has been used to obtain potentially biologically active piperidinecarboxylic acids, which have alkyl and arylalkyl radicals at the ...
Gulmira S. Akhmetova, Ulzhalgas B. Issayeva, Kaldybay D. Praliyev, Ilya S. Korotetskiy, Tulegen M. Seilkhanov, Samir A. Ross, Manas T. Omyrzakov, Ubaidilla M. Datkhayev, Khaidar S. Tassibekov, Lyudmila N. Ivanova, Natalya V. Zubenko   +10 more
doaj   +2 more sources

Highly Diastereoselective Arylations of Substituted Piperidines

, 2016
A highly diastereoselective methodology for the preparation of various substituted piperidines via Negishi cross-couplings with (hetero)aryl iodides was developed.
Hendrik Zipse (1265805), Keishi Takatsu (1830838), Tobias Thaler (2191420), Bernd F. Straub (1967926), Paul Knochel (1376235), Peter Mayer (1464436), Stephanie Seel (2213788), Cong Zhang (582922)   +7 more
core   +9 more sources

Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova, Aida Seitaliyeva, Elmira Satbayeva, Daniya Serdalieva, Talgat Nurgozhin   +4 more
doaj   +1 more source

Synthesis of piperidines and pyridine from furfural over a surface single-atom alloy Ru1CoNP catalyst

Nature Communications, 2023
The sustainable production of value-added N-heterocycles from available biomass allows to reduce the reliance on fossil resources and creates possibilities for economically and ecologically improved synthesis of fine and bulk chemicals.
Haifeng Qi, Yurou Li, Zhitong Zhou, Yueqiang Cao, Fei Liu, Weixiang Guan, Leilei Zhang, Xiaoyan Liu, Lin Li, Yang Su, K. Junge, Xuezhi Duan, Matthias Beller, Aiqin Wang, Tao Zhang   +14 more
semanticscholar   +1 more source