Results 41 to 50 of about 40,681 (241)

Synthesis of Azocanes from Piperidines via an Azetidinium Intermediate

, 2021
International audienceα-Trifluoromethyl azocanes are accessible from 2-(trifluoropropan-2-ol) piperidines by metal-free ring-expansion involving a bicyclic azetidinium intermediate.
Janine Cossy, Leverenz, Malte, Guillaume Masson, Malte Leverenz, Cossy, Janine, Pardo, Domingo Gomez, Masson, Guillaume, Domingo Gomez Pardo   +7 more
core   +1 more source

1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal structure of the title compound, C17H25N3O2, one-dimensional chains are formed via intermolecular C—H...O hydrogen bonds along the a axis.
Zhe-Qin Wang, Yi Ma
openaire   +3 more sources

Ring Expansion of Vinylaziridines through the Strain-Release Pericyclic Reaction: Recent Developments and Applications

Molecules, 2013
Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj   +1 more source

Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

Journal of Advanced Research, 2018
Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated.
Suvankar Das, Cristiane J. da Silva, Marina de M. Silva, Maria Dayanne de A. Dantas, Ângelo de Fátima, Ana Lúcia T. Góis Ruiz, Cleiton M. da Silva, João Ernesto de Carvalho, Josué C.C. Santos, Isis M. Figueiredo, Edeildo F. da Silva-Júnior, Thiago M. de Aquino, João X. de Araújo-Júnior, Goutam Brahmachari, Luzia Valentina Modolo   +14 more
doaj   +1 more source

Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines [PDF]

Journal of the Serbian Chemical Society, 2016
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine.
Penjišević Jelena Z., Šukalović Vladimir V., Andrić Deana B., Roglić Goran M., Novaković Irena T., Šoškić Vukić, Kostić-Rajačić Slađana V.   +6 more
doaj   +1 more source

Asymmetric Reduction of Pyridinium Salts to Piperidines [PDF]

Piperidines, especially chiral piperidines, have served as important structural motifs due to their great value in pharmaceutical chemistry during the last several decades.
Zhang, Shiyu
core   +1 more source

A Modular and Diastereoselective 5+1 Cyclization Approach to N-(Hetero)Aryl Piperidines.

Journal of the American Chemical Society, 2019
A new general de novo synthesis of pharmaceutically important N-(hetero)aryl piperidines is reported. This protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction se-quence to achieve rapid construction of complex ...
M. Larsen, Elisabeth T. Hennessy, Madeleine C. Deem, Yu-hong Lam, J. Saurí, Aaron C. Sather   +5 more
semanticscholar   +1 more source

Pyrrolo[3,2-c]piperidines

, 2020
The heterocyclization reaction of oximes derived from aliphatic ketones with acetylene has been applied to piperidone oximes. Pyrrole[3,2-c]piperidines substituted on the six-membered ring have been prepared in this manner.
Sergeeva N.D., Prostakov N.S., Borisova T.N., Soldatenkov A.T., Zvolinskii O.V., Astakhov A.A., Varalmov A.V.   +6 more
core   +2 more sources

‐Protected Piperidines

, 2003
Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN·2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established.
Anna M. Kauppi, Roger Olsson, Fredrik Almqvist, Kauppi, Anna M,, Wang, Xiaoyang,, Olsson, Roger, Almqvist, Fredrik,, Xiaoyang Wang   +7 more
core   +1 more source

Dialkyl Carbonates in the Green Synthesis of Heterocycles

Frontiers in Chemistry, 2019
This review focuses on the use of dialkyl carbonates (DACs) as green reagents and solvents for the synthesis of several 5- and 6-membered heterocycles including: tetrahydrofuran and furan systems, pyrrolidines, indolines, isoindolines, 1,4-dioxanes ...
Pietro Tundo, Pietro Tundo, Manuele Musolino, Fabio Aricò   +3 more
doaj   +1 more source