Results 41 to 50 of about 11,513 (251)
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles
Angewandte Chemie, EarlyView.Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley +2 more sources
4-AMINOPIPERIDINAS Y ESPIRO-4-PIPERIDINAS: IMPORTANCIA FARMACOLÓGICA Y ESFUERZOS SINTÉTICOS
Universitas Scientiarum, 2007 The piperidine compounds from natural or synthetic origin are of a great scientific interest due to his widestatus of biological activities: analgesic, neuroleptic, neurotropic, etc.
L. Y. Vargas-Méndez, V. V. Kouznetsov
doaj
Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy
Nature Communications, 2023 Six-membered N-containing heterocycles, such as 2-piperidinone derivatives, with diverse substitution patterns are widespread in natural products, drug molecules and serve as key precursors for piperidines.
Yi-Dan Du +6 more
doaj +1 more source
Advanced Science, EarlyView.A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang +19 more
wiley +1 more source
Angewandte Chemie, EarlyView.A robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Thibaud Charvillat +7 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2010 The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the ...
Heloise Brice +2 more
doaj +1 more source
Molecules, 2019 A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-free transfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester ...
Yun Fu, Jian Sun
doaj +1 more source
Molecules, 2020 Conformational analysis of Si-mono- and Si,Si-disubstituted silacyclohexanes as well as their analogues with a heteroatom(s) in the ring is reviewed with the focus on the recent results.
Bagrat A. Shainyan
doaj +1 more source