Results 61 to 70 of about 40,681 (241)

Dual‐Mode Type I/II Photosensitization of a Stable Mesoporous Hydrogen‐Bonded Organic Framework for Antibacterial Therapy

Advanced Science, EarlyView.
A π‐conjugated donor–acceptor PDI monomer undergoes hydrogen‐bonded self‐assembly to form a robust mesoporous framework. The ordered molecular arrangement promotes efficient intersystem crossing and charge separation, leading to simultaneous Type I and Type II reactive oxygen species generation with a high singlet oxygen quantum yield.
Yi‐Lun Cheng, Hui Yuan, Yuhang Li, Zi‐Yu Wang, Rui Wang, Qi Yin, Xue‐Ning Ren, Miao Zheng, Yi Zeng, Tian‐Fu Liu, Zaisheng Ye   +10 more
wiley   +1 more source

Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and Decahydroquinolines

, 2016
Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and ...
Matthew J. Wyvratt (2093320), Robert J. DeVita (523842), Jinlong Jiang (1394881), Mark T. Goulet (2443948), George A. Doss (2125201)   +4 more
core   +2 more sources

Facile and Green Synthesis of Saturated Cyclic Amines

Molecules, 2017
Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed, Sadia Javed, Razia Noreen, Tayyaba Huma, Sarosh Iqbal, Huma Umbreen, Tahsin Gulzar, Tahir Farooq   +7 more
doaj   +1 more source

Synthesis of Functionalised Piperidines Through a [3 + 3] Cycloaddition Strategy

, 2001
A novel approach to functionalised piperidines is described through a [3 + 3] cycloaddition reaction of aziridines with Pd-trimethylenemethane complexes.
Hedley, Simon J., Harrity, Joseph P. A., Moran, Wesley J., Price, David A., Prenzel, Alexander H. G. P.   +4 more
core   +1 more source

Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines

, 2018
An electrochemical aliphatic C–H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C–H amination strategy involves anodic C–
Sebastian Herold, Daniel Bafaluy, K. Muñiz   +2 more
semanticscholar   +1 more source

Gold(I)-Catalyzed Enantioselective Annulations between Allenes and Alkene-Tethered Oxime Ethers: A Straight Entry to Highly Substituted Piperidines and aza-Bridged Medium-Sized Carbocycles.

Journal of the American Chemical Society, 2018
Piperidine scaffolds are present in a wide range of bioactive natural products and are therefore considered as highly valuable, privileged synthetic targets.
David C Marcote, Iván Varela, J. Fernández-Casado, J. Mascareñas, F. López   +4 more
semanticscholar   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Piperidine-1-carboximidamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(6)H(13)N(3), the C=N and C-N bond lengths in the CN(3) unit are 1.3090 (17), and 1.3640 (17) (C-NH(2)) and 1.3773 (16) Å, indicating double- and single-bond character, respectively. The N-C-N angles are 116.82 (12), 119.08 (11) and 124.09 (11)°, showing a deviation of the CN(3) plane from an ideal trigonal-planar geometry.
openaire   +2 more sources

Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4 + 2]/[2 + 2] Cyclizations.

Organic Letters, 2017
A phosphine-catalyzed novel enantioselective [4 + 2]-annulation reaction between allene ketones and 1-azadienes has been developed, and tetrahydropyridines were obtained in good yields and with excellent enantioselectivities.
Zhen Wang, Huacheng Xu, Qin Su, Ping Hu, Pan‐Lin Shao, Yun He, Yixin Lu   +6 more
semanticscholar   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source