Results 61 to 70 of about 11,513 (251)

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

BMC Pharmacology and Toxicology, 2018
Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules.
Moses N. Ngemenya, Grace Ntube Abwenzoh, Hermia Nalova Ikome, Denis Zofou, Fidele Ntie-Kang, Simon M. N. Efange   +5 more
doaj   +1 more source

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Angewandte Chemie, EarlyView.
π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero, Manel Bosch, Rodrigo Garcés‐Castellanos, Michael Q. Schottenhamel, Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Justo P. Castaño, Tania García‐Becerra, Elena Rebollo, Marta E. Alberto, Antonio Francés‐Monerris, Vicente Marchán   +11 more
wiley   +2 more sources

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, EarlyView.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Erste Hinweise auf Ozonido‐TMC‐Komplexe von Eisen und Kobalt

Angewandte Chemie, EarlyView.
Die Umsetzung der Eisen(II)‐Komplexe [(TMC)Fe(OTf)]BArF und [(D12‐TMC)Fe(OTf)]BArF sowie der Kobalt(II)‐Komplexe [(TMC)Co(OTf)]BArF und [(D12‐TMC)Co(X)]BArF (X = OTf, F) mit Ozon führt in einem 4:1‐Gemisch aus 2‐Me‐THF und THF bei Temperaturen bis −155°C zur Bildung von Ozonido‐ und Oxido‐Komplexen.
Stefan Schaub, Dennis Gerbig, Raffael C. Wende, Heike Hausmann, Jonathan Becker, Christian Würtele, Laura Senft, Ina Kellner, Gunasekaran Velmurugan, Marion Kerscher, Ivana Ivanović‐Burmazović, Peter Comba, Joshua Telser, Peter R. Schreiner, Siegfried Schindler   +14 more
wiley   +1 more source

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP² Functionalization of Aryl and Vinyl Electrophiles

Inorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule, Christian Frabitore, Tom Livinghouse   +2 more
doaj   +1 more source

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

Beilstein Journal of Organic Chemistry, 2010
The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay, Alexandra M. Z. Slawin, David O'Hagan   +2 more
doaj   +1 more source

N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study

Future Journal of Pharmaceutical Sciences, 2018
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh   +2 more
doaj   +1 more source

Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom

Beilstein Journal of Organic Chemistry, 2020
The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied.
Giovanna Zanella, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, Enrique Gómez-Bengoa   +4 more
doaj   +1 more source

Opportunities and challenges for direct C–H functionalization of piperazines

Beilstein Journal of Organic Chemistry, 2016
Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj   +1 more source