Results 1 to 10 of about 1,211 (68)

Piperidine nucleus in the field of drug discovery

Future Journal of Pharmaceutical Sciences, 2021
Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Main text
Hussein I El-Subbagh, Khairia Youssef
exaly   +2 more sources

GC-MS analysis of the active compound in ethanol extracts of white pepper (Piper nigrum l.) and pharmacological effects [PDF]

Cellular, Molecular and Biomedical Reports, 2022
Pepper (Piper nigrum L.) has been utilized since antiquity and is considered the king of spices due to its wide use. This study aims to analyze the active compounds of white pepper through GC-MS and their pharmacological effects.
I Nyoman Arsana, Ni Juliasih, A Ayu Sauca Sunia Widyantari, Ni Suriani, Agus Manto   +4 more
doaj   +1 more source

The preparative synthetic approach to 4-(trifluoromethoxy)piperidine and 4-(trifluoromethoxymethyl)piperidine

Журнал органічної та фармацевтичної хімії, 2021
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion.
Ivan G. Logvinenko, Violetta G. Dolovanyuk, Ivan S. Kondratov   +2 more
doaj   +1 more source

Application of Chiral Piperidine Scaffolds in Drug Design

Pharmaceutical Fronts, 2023
Chiral piperidine scaffolds are prevalent as the common cores of a large number of active pharmaceuticals in medical chemistry. This review outlined the diversity of chiral piperidine scaffolds in recently approved drugs, and also covers the scaffolds in
Qiu-Shi Chen, Jian-Qi Li, Qing-Wei Zhang
doaj   +1 more source

Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents

Molecules
Diabetes mellitus is a severe endocrine disease that affects more and more people every year. Modern medical chemistry sets itself the task of finding effective and safe drugs against diabetes.
Beatriz Giner, Darya Zolotareva, Alexey Zazybin   +2 more
exaly   +3 more sources

Overview of Piperidine and Morpholine Derivatives as Promising Sources of Biologically Active Compounds (Review)

Разработка и регистрация лекарственных средств, 2023
Introduction. The search for new, effective and safe pharmacologically active substances remains an urgent task in the field of pharmacy. Many compounds of the piperidine and morpholine series are widely used in medical practice and belong to an ...
A. E. Khamitova, D. A. Berillo
doaj   +1 more source

μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation [PDF]

Journal of the Serbian Chemical Society, 2020
Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for μ-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperidine and N-aryl
Jevtić Ivana I., Penjišević Jelena Z., Savić-Vujović Katarina R., Srebro Dragana P., Vučković Sonja M., Ivanović Milovan D., Kostić-Rajačić Slađana V.   +6 more
doaj   +1 more source

Microwave-Assisted Synthesis of (Piperidin-1-yl)quinolin-3-yl)methylene)hydrazinecarbothioamides as Potent Inhibitors of Cholinesterases: A Biochemical and In Silico Approach

Molecules, 2021
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, characterized by central cognitive dysfunction, memory loss, and intellectual decline poses a major public health problem affecting millions of people around the globe.
Rubina Munir, Muhammad Zia-ur-Rehman, Shahzad Murtaza, Sumera Zaib, Noman Javid, Sana Javaid Awan, Kiran Iftikhar, Muhammad Makshoof Athar, Imtiaz Khan   +8 more
doaj   +1 more source

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

Molecules, 2023
Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases.
Victor P. Krasnov, Irina A. Nizova, Alexey Yu. Vigorov, Tatyana V. Matveeva, Galina L. Levit, Mikhail I. Kodess, Marina A. Ezhikova, Pavel A. Slepukhin, Dmitry A. Bakulin, Ivan N. Tyurenkov, Valery N. Charushin   +10 more
doaj   +1 more source

Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach

Molecules, 2020
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives ...
Elisa Bonandi, Giada Tedesco, Dario Perdicchia, Daniele Passarella   +3 more
doaj   +1 more source