Results 21 to 30 of about 38,750 (255)

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Molecules, 2017
A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references).
Sarah Rioton, Domingo Gomez Pardo, Janine Cossy   +2 more
doaj   +1 more source

Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides

Molecules, 2021
A series of new acetamide derivatives 22–28 of primary and secondary amines and para-toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two
Abdulmajeed S. H. Alsamarrai, Saba S. Abdulghani   +1 more
doaj   +1 more source

PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

Beilstein Journal of Organic Chemistry, 2011
PEG-embedded potassium tribromide ([K+PEG]Br3−) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester.
Sanny Verma, Suman L. Jain, Bir Sain
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)

Acta Crystallographica Section E: Crystallographic Communications
In the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules
Imane Maimoune, Benson M. Kariuki, Abderrazzak El Moutaouakil Ala Allah, Intissar Nchioua, Abdulsalam Alsubari, Joel T. Mague, Abdelkader Zarrouk, Youssef Ramli   +7 more
doaj   +1 more source

Crystal structure of 4-chloro-N-{[1-(4-chlorobenzoyl)piperidin-4-yl]methyl}benzamide monohydrate

Acta Crystallographica Section E, 2014
In the title compound, C20H20Cl2N2O2·H2O, the piperidine ring adopts a chair conformation with the two substituent benzene rings inclined to one another [dihedral angle 84.63 (9)°].
K. Prathebha, D. Reuben Jonathan, S. Sathya, J. Jovita, G. Usha   +4 more
doaj   +1 more source

Design and synthesis of various 1,3,4-oxadiazoles as AChE and LOX enzyme inhibitors

Heterocyclic Communications, 2023
N-Substituted-2-propanamide analogues of 1,3,4-oxadiazole have been synthesized using a multi-step synthetic protocol to explore new therapeutic anti-enzymatic agents.
Iqbal Javed, Mallhi Ali Imran, ur Rehman Aziz, Al-Mijalli Samiah H., un-Nisa Mehr, Zafar Fatiqa, Shahzad Sohail, Rasool Shahid, Iqbal Munawar, Shah Syed Adnan Ali   +9 more
doaj   +1 more source

Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring

Beilstein Journal of Organic Chemistry, 2010
We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety.
Arumugam Kodimuthali, Padala Lakshmi Prasunamba, Manojit Pal   +2 more
doaj   +1 more source

The crystal structure and Hirshfeld surface analysis of 1-(2,5-dimethoxyphenyl)-2,2,6,6-tetramethylpiperidine

Acta Crystallographica Section E: Crystallographic Communications, 2020
In the title compound, C17H27NO2, the piperidine ring has a chair conformation and is positioned normal to the benzene ring. In the crystal, molecules are linked by C—H...O hydrogen bonds, forming chains propagating along the c-axis direction.
Mustapha Tiouabi, Raphaël Tabacchi, Helen Stoeckli-Evans   +2 more
doaj   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification

Angewandte Chemie, EarlyView.
Herein, we present a method for carbon isotope labeling of arylamides via the coupling of air‐stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes.
Daniel V. Hoffmann, Anika Schick, Lasse Kjær, Vitus J. Enemærke, Clemens Kaussler, Jens Torp, Pablo Martínez‐Pardo, Charles S. Elmore, Troels Skrydstrup   +8 more
wiley   +2 more sources