Molecules, 2013 D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose.
Chu-Yi Yu +4 more
doaj +2 more sources
Bicyclic Bioisosteres of Piperidine: Version 2.0 [PDF]
, 2023 1-Azaspiro[3.3]heptanes were synthesized, characterized, and validated biologically in vivo as a new generation of saturated piperidine ...
Dmitry , Granat +13 more
core +2 more sources
Dewar Pyridines: Conformationally Programmable Piperidine Isosteres [PDF]
, 2023 Bioisosteric replacement is an indispensable tool in the medicinal chemist’s arsenal to strike a fine balance in multiparameter optimization campaigns and to deliver the best molecules for further preclinical development.
Jan, Petrovcic +7 more
core +2 more sources
Synthesis of heterocyclic bromacetylene alcohols and their acryl -, methacryl ethers
Алматы технологиялық университетінің хабаршысы, 2021 The article presents a method for obtaining heterocyclic bromoacetylenic alcohols by the action of sodium hypobromide on cyclic and heterocyclic acetylene alcohols, as well as their acrylic and methacrylic esters using lithium aluminum complexes.
T. A. Yagudeev +3 more
doaj +1 more source
Ag(I)/PPh3-Catalyzed Diastereoselective Syntheses of the Spiro[indole-3,4\u27-piperidine] Scaffold and Its Derivatives via Chelation-Controlled Cycloisomerizations of Tryptamine-Ynamides [PDF]
, 2021 A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4\u27-piperidine] scaffold.
Maosheng, Cheng +9 more
core +2 more sources
Copper ion-catalyzed regioselective introduction of active methylene groups into the γ-position of piperidine skeleton and its application to the synthesis of (-)-cincholoiponic acid [PDF]
, 2006 Copper ion-catalyzed regioselective introduction of active methylene groups into the γ-position of piperidine skeleton was exploited. In the case of using chiral ligand as an additive, this reaction proceeded with moderate enantioselectivities.
Matsumura, Yoshihiro +4 more
core +1 more source
Beyond the Simple Copper(II) Coordination Chemistry with Quinaldinate and Secondary Amines
Molecules, 2020 Copper(II) acetate has reacted in methanol with quinaldinic acid (quinoline-2-carboxylic acid) to form [Cu(quin)2(CH3OH)]∙CH3OH (1) (quin− = an anionic form of the acid) with quinaldinates bound in a bidentate chelating manner.
Barbara Modec, Nina Podjed, Nina Lah
doaj +1 more source
Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study [PDF]
, 2011 Electronic structure methods have been applied to calculate the gas and aqueous phase reaction energies for base-induced rearrangements of N-chloropiperidine, N-chloro-3-(hydroxymethyl)piperidine, and N-chloro-4-4-fluorophenyl)-3-(hydroxymethyl ...
Sakic, Davor +5 more
core +1 more source
Frontiers in Chemistry, 2020 The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective
Ana Maria Faisca Phillips +2 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2021 The title compounds, 8-{1-[3-(cyclopent-1-en-1-yl)benzyl]piperidin-4-yl}-2-methoxyquinoline, C27H30N2O (I), and 8-{4-[3-(cyclopent-1-en-1-yl)benzyl]piperazin-1-yl}-2-methoxyquinoline, C26H29N3O (II), differ only in the nature of the central six-membered ...
Nisar Ullah, Helen Stoeckli-Evans
doaj +1 more source