Results 41 to 50 of about 38,755 (162)

Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]

Journal of the Serbian Chemical Society, 2019
A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I., Penjišević Jelena Z., Ivanović Milovan D., Kostić-Rajačić Slađana V.   +3 more
doaj   +1 more source

Pharmacological and biochemical characteristics of blood of different groups of animals during treatment piperidine 2-(5-furan-2-yl)-4-phenyl-1,2,4-triazol-3-iltioatsetat

Zaporožskij Medicinskij Žurnal, 2013
A study of blood biochemical parameters of different groups of animals on a background of piperidine 2 - (5-furan-2-yl)-4-phenyl-1,2,4-triazol-3-iltioatsetat.
V. V. Parchenko , L. I. Parhomenko, V. Y. Izdepsky   +2 more
doaj   +1 more source

(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

IUCrData, 2017
In the title molecule, C13H17NO2, the piperidine ring assumes a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 45.49 (1)°.
S. Gomathi, D. Reuben Jonathan, U. Mohamooda Sumaya, E. R. A. Dravida Thendral, G. Usha   +4 more
doaj   +1 more source

PIPERIDIN AS AN ANÆSTHETIC AND SEDATIVE [PDF]

The Journal of Nervous and Mental Disease, 1883
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openaire   +2 more sources

Crystal structures of two chiral piperidine derivatives: 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one and 8-[(1S)-1-phenylethyl]-1,4-dioxa-8-azaspiro[4.5]decane-7-thione

Acta Crystallographica Section E: Crystallographic Communications, 2015
The crystal structures of the two title piperidine derivatives show different conformations for the six-membered heterocycle. The N-substituted 4-piperidinone 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one, C13H17NO2, (I), has a chair conformation ...
Nancy Romero, Sylvain Bernès, Luis F. Roa, Joel L. Terán, Dino Gnecco   +4 more
doaj   +1 more source

Tetrakis(μ-benzoato-κ2O:O′)bis[(piperidine-κN)rhodium]

IUCrData, 2017
The title compound, [Rh2(C7H5O2)4(C5H11N)2], an adduct of dimeric rhodium(II) benzoate with piperidine, was prepared. The complex lies across an inversion centre with the unique RhII ion in a slightly distorted octahedral coordination environment.
Detlef Selent, Hans-Joachim Drexler
doaj   +1 more source

Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Tubulin polymerisation inhibitors that target colchicine binding site were powerful anticancer agents. Although along the years many colchicine binding site inhibitors (CBSIs) have been reported, few piperidine derivatives were identified as CBSIs.
Dong-Jun Fu, Si-Meng Liu, Jia-Jia Yang, Jun Li   +3 more
doaj   +1 more source

Comparison of In Silico AChE Inhibitory Potentials of Some Donepezil Analogues

Pharmata
Cholinesterases are important in ensuring hemostasis in our body. Excessive increase in cholinesterase function causes various cholinergic dysfunctions. Alzheimer's is a disease characterized by loss of cholinergic activity, which is especially common in
Mehmet Koca
doaj  

Piperidine-1-carboximidamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(6)H(13)N(3), the C=N and C-N bond lengths in the CN(3) unit are 1.3090 (17), and 1.3640 (17) (C-NH(2)) and 1.3773 (16) Å, indicating double- and single-bond character, respectively. The N-C-N angles are 116.82 (12), 119.08 (11) and 124.09 (11)°, showing a deviation of the CN(3) plane from an ideal trigonal-planar geometry.
openaire   +2 more sources

Investigating the preparation of oxime derivatives of azacrown ethers containing piperidine-4-one heterocycles under microwave irradiation

Vietnam Journal of Science, Technology and Engineering
The use of multi-component reactions to simultaneously synthesise crown ethers and nitrogen-containing heterocycles is a synthetic approach that has attracted significant interest. With nitrogen heterocycles embedded in their structures, azacrown ethers
Tung H. To, Hieu D. Nguyen
doaj   +1 more source