Results 31 to 40 of about 52,734 (205)

PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

Beilstein Journal of Organic Chemistry, 2011
PEG-embedded potassium tribromide ([K+PEG]Br3−) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester.
Sanny Verma, Suman L. Jain, Bir Sain
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)

Acta Crystallographica Section E: Crystallographic Communications
In the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules
Imane Maimoune, Benson M. Kariuki, Abderrazzak El Moutaouakil Ala Allah, Intissar Nchioua, Abdulsalam Alsubari, Joel T. Mague, Abdelkader Zarrouk, Youssef Ramli   +7 more
doaj   +1 more source

Crystal structure of 4-chloro-N-{[1-(4-chlorobenzoyl)piperidin-4-yl]methyl}benzamide monohydrate

Acta Crystallographica Section E, 2014
In the title compound, C20H20Cl2N2O2·H2O, the piperidine ring adopts a chair conformation with the two substituent benzene rings inclined to one another [dihedral angle 84.63 (9)°].
K. Prathebha, D. Reuben Jonathan, S. Sathya, J. Jovita, G. Usha   +4 more
doaj   +1 more source

Design and synthesis of various 1,3,4-oxadiazoles as AChE and LOX enzyme inhibitors

Heterocyclic Communications, 2023
N-Substituted-2-propanamide analogues of 1,3,4-oxadiazole have been synthesized using a multi-step synthetic protocol to explore new therapeutic anti-enzymatic agents.
Iqbal Javed, Mallhi Ali Imran, ur Rehman Aziz, Al-Mijalli Samiah H., un-Nisa Mehr, Zafar Fatiqa, Shahzad Sohail, Rasool Shahid, Iqbal Munawar, Shah Syed Adnan Ali   +9 more
doaj   +1 more source

Observation of Piperidine aggregation and of Hydrogen-proton transfer between Piperidine radical cations and Piperidine molecules in Freon matrice : an E.S.R. study at cryogenic temperaturs

, 1992
Piperidine forms small aggregates in most Freon matrices at cryogenic temperatures; upon X-irradiation, hydrogen-proton transfer between piperidine radical cations and piperidine molecules occurs.
Sjöqvist, L., Antzutkin, Oleg, Lindgren, M.,, Lund, A.   +3 more
core   +1 more source

Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring

Beilstein Journal of Organic Chemistry, 2010
We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety.
Arumugam Kodimuthali, Padala Lakshmi Prasunamba, Manojit Pal   +2 more
doaj   +1 more source

The crystal structure and Hirshfeld surface analysis of 1-(2,5-dimethoxyphenyl)-2,2,6,6-tetramethylpiperidine

Acta Crystallographica Section E: Crystallographic Communications, 2020
In the title compound, C17H27NO2, the piperidine ring has a chair conformation and is positioned normal to the benzene ring. In the crystal, molecules are linked by C—H...O hydrogen bonds, forming chains propagating along the c-axis direction.
Mustapha Tiouabi, Raphaël Tabacchi, Helen Stoeckli-Evans   +2 more
doaj   +1 more source

Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study [PDF]

, 2011
Electronic structure methods have been applied to calculate the gas and aqueous phase reaction energies for base-induced rearrangements of N-chloropiperidine, N-chloro-3-(hydroxymethyl)piperidine, and N-chloro-4-4-fluorophenyl)-3-(hydroxymethyl ...
Sakic, Davor, Hendrik Zipse, Davor Šakić, Vrcek, Valerije, Valerije Vrček, Zipse, Hendrik   +5 more
core   +1 more source

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives

Molecules, 2020
In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting
Rokhyatou Seck, Abdoulaye Gassama, Sandrine Cojean, Christian Cavé   +3 more
doaj   +1 more source

Asymmetric piperidine synthesis [PDF]

, 1995
It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers'
Lewis, Neil
core