Results 61 to 70 of about 38,750 (255)

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

THE TREATMENT OF GOUT BY PIPERIDINE. [PDF]

The Lancet, 1898
n ...
openaire   +2 more sources

Pharmacological and biochemical characteristics of blood of different groups of animals during treatment piperidine 2-(5-furan-2-yl)-4-phenyl-1,2,4-triazol-3-iltioatsetat

Zaporožskij Medicinskij Žurnal, 2013
A study of blood biochemical parameters of different groups of animals on a background of piperidine 2 - (5-furan-2-yl)-4-phenyl-1,2,4-triazol-3-iltioatsetat.
V. V. Parchenko , L. I. Parhomenko, V. Y. Izdepsky   +2 more
doaj   +1 more source

Ein Ruthenium‐(Ph‐BPE) Katalysator für die asymmetrische Alkinylierung von Fluoral: Enantioselektion aus einem von 12 fluxionalen Komplexen mit rutheniumzentrierter Stereogenität

Angewandte Chemie, EarlyView.
Dies beschreibt die ersten enantioselektiven Alkinylierungen wässrigen Fluorals. Diese Prozesse werden durch einen Iodid‐gebundenen Ruthenium‐(Ph‐BPE)‐Komplex katalysiert, welcher als oktaedrischer Metallkomplex in 12 verschiedenen stereoisomeren Formen vorliegen kann.
Weijia Shen, Sebastian Höthker, Colin E. Hayter, Nicholas K. Bowers, Andrea Pellegrini, Stefan Grimme, Michael J. Krische   +6 more
wiley   +1 more source

(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

IUCrData, 2017
In the title molecule, C13H17NO2, the piperidine ring assumes a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 45.49 (1)°.
S. Gomathi, D. Reuben Jonathan, U. Mohamooda Sumaya, E. R. A. Dravida Thendral, G. Usha   +4 more
doaj   +1 more source

Crystal structures of two chiral piperidine derivatives: 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one and 8-[(1S)-1-phenylethyl]-1,4-dioxa-8-azaspiro[4.5]decane-7-thione

Acta Crystallographica Section E: Crystallographic Communications, 2015
The crystal structures of the two title piperidine derivatives show different conformations for the six-membered heterocycle. The N-substituted 4-piperidinone 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one, C13H17NO2, (I), has a chair conformation ...
Nancy Romero, Sylvain Bernès, Luis F. Roa, Joel L. Terán, Dino Gnecco   +4 more
doaj   +1 more source

Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti-Inflammatory Properties. [PDF]

ChemMedChem
In this work, we identified two novel pleiotropic sinapic acid derivatives with excellent anti‐acetylcholinesterase, antioxidant, and anti‐inflammatory properties. Alzheimer's disease, one of the most widespread neurodegenerative disorders, is known for its multifactorial nature that makes it challenging to treat.
Sdougkou K, Rekka E, Papagiannopoulou D.
europepmc   +2 more sources

Tetrakis(μ-benzoato-κ2O:O′)bis[(piperidine-κN)rhodium]

IUCrData, 2017
The title compound, [Rh2(C7H5O2)4(C5H11N)2], an adduct of dimeric rhodium(II) benzoate with piperidine, was prepared. The complex lies across an inversion centre with the unique RhII ion in a slightly distorted octahedral coordination environment.
Detlef Selent, Hans-Joachim Drexler
doaj   +1 more source

Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Tubulin polymerisation inhibitors that target colchicine binding site were powerful anticancer agents. Although along the years many colchicine binding site inhibitors (CBSIs) have been reported, few piperidine derivatives were identified as CBSIs.
Dong-Jun Fu, Si-Meng Liu, Jia-Jia Yang, Jun Li   +3 more
doaj   +1 more source