Results 81 to 90 of about 103,451 (274)

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

(2,4-Dichlorophenyl)(3-hydroxypiperidin-1-yl)methanone: crystal structure and Hirshfeld analysis

IUCrData, 2017
In the title compound, C12H13Cl2NO2, the piperidine ring adopts a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 58.5 (3)°.
U. Mohamooda Sumaya, D. Reuben Jonathan, Dravida Thendral Era, S. Gomathi, G. Usha   +4 more
doaj   +1 more source

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

, 2014
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F., Dominey, Andrew P., Harrowven, David C., Linclau, Bruno   +3 more
core   +2 more sources

Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids [PDF]

, 2012
A base-mediated 6-endo-trig cyclization of readily accessible enone-derived α-amino acids has been developed for the direct synthesis of novel 2,6-cis-6- substituted-4-oxo-L-pipecolic acids. A range of aliphatic and aryl side chains were tolerated by
Agami C., Alastair A. Cant, Andrew Sutherland, Bernasconi R., Boger D. L., Cant A. A., Carbonnel S., Fowler L. S., Fowler L. S., Golubev A., Graham L. Simpson, Gutiérrez M. C., Hans Martin Senn, He M., Ireland R. E., Jatoi W. B., Johnson F., Jung J.-C., Kadouri-Puchot C., Lamarre D., Lindsay S. Fowler, Marin J., Mark Daly, Merino P., Occhiato E. G., Occhiato E. G., Purkayastha N., Purkayastha N., Romeo J. T., Romo D., Rudisill D. E., Schenk V. W., Smith A. B., Smith A. B., Smith A. B., Swindells D. C., Tanaka H., Vanderhaeghe H., Weigend F., Zacharius R. M., Zhao Y., Zhao Y.   +41 more
core   +1 more source

Rational Design of Ni3+‐Rich Nickel Nitride Enables Paired Electrooxidation of Sterol and Hydrogen Evolution in a Flow Electrolyzer

Advanced Science, EarlyView.
The rational design of Ni3+‐rich active sites on nickel nitride nanosheets via Pd‐induced electronic modulation, which was employed in the electrooxidation of sterol coupled with H2 production in a large flow electrolyzer. This work offers a novel strategy for the design and synthesis of highly efficient electrocatalysts and electrolyzers toward the ...
Suiqin Li, Jieyu Wang, Ge Feng, Jiahui He, Kai Li, Lihao Liu, Yuhang Wang, Zixian Jia, Yanfei Xu, Wenwu Zhong, Xing Zhong, Jianguo Wang   +11 more
wiley   +1 more source

Crystal structure of 3-methyl-2,6-bis(4-methyl-1,3-thiazol-5-yl)piperidin-4-one

Acta Crystallographica Section E, 2014
In the title compound, C14H17N3OS2, the central piperidinone ring adopts a chair conformation and the thiazole rings are inclined to its mean plane by 80.16 (12) and 67.15 (12)°.
A. Manimaran, K. Sethusankar, S. Ganesan, S. Ananthan   +3 more
doaj   +1 more source

Sodium piperidine-1-carbodithioate dihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The asymmetric unit of the title compound, Na(+)·C(6)H(10)NS(2) (-)·2H(2)O, is composed of a sodium cation, a piperidine-dithio-carbamate anion which exhibits positional disorder, and two lattice water mol-ecules. The atoms of the piperidine ring are divided over two sites with occupancy factors of 0.554 (6) and 0.446 (6).
Ana C. Mafud, Maria Teresa P. Gambardella   +1 more
openaire   +3 more sources

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]

, 2010
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright, Anton Bunschoten, B Postma, B Postma, BO Gerber, Carla J. C. de Haas, CE Stotz, DE Epps van, F Blanco, H Lee, J Cavanagh, JH Ippel, JJ Chen, Johan Kemmink, Johannes H. Ippel, John A. W. Kruijtzer, KE Veldkamp, LM Proctor, Louris Feitsma, M Allegretti, M Farzan, PJ Haas, PN Monk, RF Guo, Rob M. J. Liskamp, TS Haque, ZG Chen   +26 more
core   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, EarlyView.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima

Molecules, 2017
Four novel compounds—two phenylpropionamides, one piperidine, and one phenolic derivatives—were isolated and identified from the fruit of a medicinal plant, Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with one known phenylpropionamide ...
Jian-Cheng Ni, Jian-Ting Shi, Qing-Wei Tan, Qi-Jian Chen   +3 more
doaj   +1 more source