Results 101 to 110 of about 38,750 (255)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, EarlyView.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source
Development of High-Affinity CHD1 Chromodomain Inhibitors. [PDF]
J Med ChemGreschik H +32 more
europepmc +1 more source
Cyclometalated Au(III) Complexes With C*N^N, N^C*N, and C*N Ligands Through C–H Activation
Zeitschrift für anorganische und allgemeine Chemie, EarlyView.The complexes [Au(QPhPy)Cl][AuCl4], [Au(QPhCF3Py)Cl][AuCl4], [Au(QPhtBuPy)Cl][AuCl4], [Au(QPhPy)Cl]Cl, [Au(QPyPh)Cl2], [Au(QPyPhCF3)Cl2], [Au(QPyPhtBu)Cl2], [Au(bpyAn)Cl][AuCl4], and [Au(phenAn)Cl][AuCl4] (Q = 8‐quinolinyl, Ph = phenyl, An = anthracen‐9‐yl, Py = pyridyl, bpy = 2,2′′‐bipyridyl, phen = 1,10‐phenanthrolinyl) containing N*C^N, N*C, and NN ...
Pascal L. Jurzick +5 more
wiley +1 more source
Unusual backfolded binding poses of BAZ2A bromodomain binders
Acta Crystallographica Section D, EarlyView.We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove +5 more
wiley +1 more source
Novel 3‑Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia. [PDF]
ACS Med Chem LettSabnis RW.
europepmc +1 more source