Results 111 to 120 of about 103,451 (274)
Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
Chemistry – A European Journal, EarlyView.We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley +1 more source
Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]
, 2006 Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner +9 more
core +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion
Chemistry – A European Journal, EarlyView.Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato +4 more
wiley +1 more source
Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential [PDF]
, 2012 A
Esposito +12 more
core +2 more sources
Drug Testing and Analysis, EarlyView.ABSTRACT Hair analysis is increasingly used in forensic toxicology; however, result interpretation may be influenced by cosmetic hair treatments. Although the effects of bleaching, dyeing, and thermal straightening have already been evaluated, data on permanent chemical hair straightening are scarce, particularly under in vivo conditions.
Miriam Blanco‐Ces +5 more
wiley +1 more source
Crystal structure of 2-chloro-1-(3-methyl-2,6-diphenylpiperidin-1-yl)ethanone
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C20H22ClNO, the piperidine ring has a twist-boat conformation. There is an intramolecular C—H...π interaction involving the two phenyl rings which are inclined to one another by 84.91 (7)°.
V. Shreevidhyaa Suressh +4 more
doaj +1 more source
Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]
, 2008 1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert +5 more
core +2 more sources
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Scheme of the synergistic degradation for antibiotic micropollutants in the Cu/ag‐C3N4 system. Photocatalytic processes driven by visible‐light irradiation offer a sustainable means of micropollutants removal from aquatic environments without the addition of reagents.
Xiaozhe Song +12 more
wiley +1 more source
, 2015 A series of highly functionalized piperidine derivatives was synthesized through one-pot, five-component reaction of aldehydes, amines, and β-ketoesters.
W. Basyouni +3 more
semanticscholar +1 more source