Results 111 to 120 of about 38,750 (255)

Piperidines [PDF]

Chemical & Engineering News Archive, 1978
openaire   +1 more source

Investigation of eosin Y as a colorimetric sensor for the detection of fentanyl hydrochloride and fentanyl freebase

Journal of Forensic Sciences, EarlyView.
Abstract The increasing prevalence of fentanyl within the illegal global drug market underscores the need for rapid, low‐cost, and straightforward detection methods. Eosin Y demonstrates a measurable color change in the presence of fentanyl, making it a promising candidate for colorimetric sensing and preliminary identification of fentanyl ...
Alan J. Zhou, Melissa M. Dixon, Brady S. Gentle, Genevieve H. Dennison, Kellie L. Tuck   +4 more
wiley   +1 more source

Deaminative Fluorination of Sulfonamides via Aminocyclopropenium Activation. [PDF]

Org Lett
Carneiro SN, Bento JV, Zimmerman PM, Sanford MS.   +3 more
europepmc   +1 more source

Evaluation of illicit drug contaminants in seized cannabis in Arizona and California, 2023–2024

Journal of Forensic Sciences, EarlyView.
Abstract Despite public health concerns, fentanyl, cocaine, and other illicit drug contaminants remain largely understudied in unregulated cannabis. Here, we developed an analytical method to quantify a panel of common illicit drugs in cannabis and tested the law enforcement seizures in Arizona and California in evaluation of the illicit drug ...
Beckner Andersano, Thomas M. Cahill, Michael Grommes, Maxwell C. K. Leung   +3 more
wiley   +1 more source

Regioselective green synthesis of some novel indole-substituted 1<i>H</i>-benzo[<i>f</i>]chromenes <i>via</i> one-pot three-component reactions in water-ethanol media. [PDF]

RSC Adv
Khanmohammadi A, Olyaei A, Sadeghpour M.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Recent advances in piperine and its derivatives as potential anticancer agents. [PDF]

RSC Med Chem
Yu QH, Liu Z, Liu J, Bai LP.
europepmc   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Sulfonyl Anthranilic Acid Analogues Display Pan-Serotype Anti-Dengue Activity by Downregulating the Expression of Ribosomal Proteins Encoded by 5'-Terminal Oligopyrimidine Motif-Containing mRNA. [PDF]

J Med Chem
Gwee CP, Felicetti T, Chan KWK, Tan MJA, Bin Mohd Mazlan MD, Milite C, Pepe G, Sarnari C, Ng XD, Phoo WW, Tan JHY, Mah MG, Watanabe S, Huang JX, Massari S, Tabarrini O, Sabatini S, Campiglia P, Sbardella G, Smith GJD, Alonso S, Sun AX, Sobota RM, Vasudevan SG, Manfroni G.   +24 more
europepmc   +1 more source