Results 131 to 140 of about 103,451 (274)

Synthesis, docking, pharmacokinetic prediction, and acetylcholinesterase inhibitory evaluation of N-(2-(piperidine-1-yl)ethyl)benzamide derivatives as potential anti-Alzheimer agents

Research in Pharmaceutical Sciences
Background and purpose: Alzheimer’s disease is the most common form of dementia and the sixth most common cause of death in the US according to the Alzheimer’s Association.
Ahmad Mohammadi-Farani, Farzaneh Moradi, Amin Hosseini, Alireza Aliabadi   +3 more
doaj   +1 more source

Untersuchungen zur trägerarmen Radiofluorierung nicht-aktivierter Aromaten mit n.c.a. [18F]Fluorid [PDF]

, 2011
In vivo imaging with positron emission tomography generally demands radiotracers with a high specific activity. In case of fluorine-18 the required no-carrier-added (n.c.a.) starting material is only available in form of fluoride. This and the short half-
Cardinale, Jens
core  

Dearomatization with Axial‐to‐Central Chirality Conversion

European Journal of Organic Chemistry, EarlyView.
Atropisomers are exciting synthetic targets with unique properties, which find applications in many fields of chemistry. However, considering them as substrates is not very frequent, notably in the context of dearomatization reaction. We wish to discuss the different strategies for the dearomatization of aromatic atropisomers with axial‐to‐central ...
Morgane Mando, Clément Lemaitre, Thierry Constantieux, Xavier Bugaut   +3 more
wiley   +1 more source

Liesegang patterns: Effect of dissociation of the invading electrolyte

, 1998
The effect of dissociation of the invading electrolyte on the formation of Liesegang bands is investigated. We find, using organic compounds with known dissociation constants, that the spacing coefficient, 1+p, that characterizes the position of the n-th
Antal T., Chopard B., Dee G. T., Dhar N. R., Feeney R., Flicker M., Gálfi L., Henisch H. K., Jablczynski K., Kai S., Liesegang R. E., Matalon R., Morse W., Ostwald W., Packter A., Prager S., Shinohara S., Smith D. A., Venzl G., Wagner C., Zeldovitch Ya. B., Zrinyi M.   +21 more
core   +1 more source

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

Molecules, 2019
GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

C-2,8,14,20-tetra(propyl)-5,11,17,23-tetrakis(N–(piperidine)methyl)calix[4]resorcinarene

Molbank
Calix[4]resorcinarenes are polyhydroxylated macrocyclic compounds with four units of resorcinol. These compounds can be derivatized through modifications at the upper rim, allowing reactivity with secondary amines to produce Mannich base derivatives via ...
Victor Alfonso Niño-Ramírez, Zuly Jenny Rivera-Monroy, Mauricio Maldonado   +2 more
doaj   +1 more source

SYNTHESIS AND CATECHOLASE ACTIVITY OF Cu(II) AND Fe(III) COMPLEXES OF 4-METHYL-2-((PIPERIDIN-1-YL)METHYL)PHENOL

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2020
This study is aimed at evaluating the impact of N- and S- bonding modes of thiocyanate substituent on catecholase activity as its presence in the coordination sphere of the metal complex can either reduce catecholase activity or otherwise. 4-Methyl-2-(
AYOWOLE O. AYENI, GARETH M. WATKINS 1
doaj  

Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. [PDF]

, 2019
Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the
Finkbeiner, Walter E, Haggie, Peter M, Nielson, Dennis W, Phuan, Puay-Wah, Rivera, Amber A, Tan, Joseph-Anthony, Verkman, Alan S, Zlock, Lorna   +7 more
core  

Identification of Novel Piperidine and Pyrrolidine Derivatives as Potent Inhibitors of Pancreatic Lipase-Based Molecular Docking and In Vitro Testing

Scientia Pharmaceutica
Obesity is a major global health concern associated with increased risks of chronic diseases and mortality. Inhibiting pancreatic lipase, a key enzyme in dietary fat absorption, presents a promising therapeutic approach.
Acharaporn Duangjai, Kwanruthai Tadpetch, Vatcharin Rukachaisirikul, Chutima S. Vaddhanaphuti, Maleeruk Utsintong   +4 more
doaj   +1 more source

Stereo-Control in Zn(II) and Cd(II) Complexes of Tetraamines with Azacyclic Cores

Inorganics
Halide-dictated stereoselective formation of octahedral Δ-cis-α-[Zn(L)Cl2] or trigonal bipyramidal Λ-[Zn(L)I]I, where L is a chiral tetramine with a pyrrolidine or piperidine core, has been observed in both the solid state and in solution through a ...
Hanan A. A. Althobaiti, Benson M. Kariuki, Grace Lancey, James A. Platts, Olivia Ann Westland, Paul David Newman   +5 more
doaj   +1 more source