Results 141 to 150 of about 38,750 (255)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Total Syntheses of (+)-Hyperbeanols A-C, (+)-Hyperpatulol A, and (-)-Hypercohone G, as Well as Structure Revision of Hyperpatulol A, and Hyperbeanol B. [PDF]

JACS Au
Liu X, Ma T, Bai Y, Lu Z, Zhang Y, Shao Z, Jia Y.   +6 more
europepmc   +1 more source

A Hydrogen‐Bonded Organic Biradical in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 7, July 2026.
Hydrogen‐bonded dimers of the TEMPOL radical are investigated by vibrational spectroscopy in the gas phase and shown to occur in at least two conformations, a stretched one with a strong hydrogen bond to the radical centre and a bent one with more pronounced London dispersion interactions. ABSTRACT Persistent organic radicals from the TEMPO family such
Dana Donnerstag, Elisabeth Sennert, Martin A. Suhm   +2 more
wiley   +1 more source

Kabbe condensation: a comprehensive review of spirochromanone synthesis and medicinal applications. [PDF]

RSC Adv
Samandram R, Komarasamy B, Murugan P, Jayaraj P, Vemparala M, Fareed Chaman A, Anaikutti P.   +6 more
europepmc   +1 more source

A Single Hydrophobic Residue Enhances the Uptake of Short Cationic Proline‐Rich Cell‐Penetrating Peptides

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The introduction of a single hydrophobic residue at the C‐terminus of short cationic peptides enhances passive translocation and cellular uptake. ABSTRACT Cationic cell‐penetrating peptides (CPPs) are a versatile platform for intracellular cargo delivery into mammalian cells but often suffer from low cellular uptake and endosomal entrapment.
Adeline Schmitt, Helma Wennemers
wiley   +1 more source

Aldehyde–Olefin Couplings by Photoinduced Reduction of Electron‐Deficient Olefins with Hantzsch Ester Anions

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Single‐electron transfer‐mediated reductive carbonyl–olefin couplings are valuable carbon–carbon bond forming reactions. However, limitations persist for couplings of aliphatic aldehydes with electron‐deficient olefins. Here, we report a simple, photocatalyst‐free protocol that overcomes these limitations by using a Hantzsch ester anion as a ...
Zhihang Li, Adam Noble
wiley   +2 more sources

Immobilized Activation Base for Solid-Phase Peptide Synthesis in Flow. [PDF]

J Org Chem
Wettler A, Tamás B, Hartrampf N.
europepmc   +1 more source

REILLY PIPERIDINES [PDF]

Chemical & Engineering News Archive, 1963
openaire   +1 more source

Radiolabeled Angiopep‐2 Peptide Vector as a Preclinical Platform for Blood–Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The developed DOTA‐Angiopep‐2 conjugate was well tolerated in glioma cells and enabled high‐yield radiolabeling with 177Lu and 161Tb. The 161Tb conjugate showed brain delivery with predominantly renal clearance, supporting a stable radiotheranostic platform for BBB‐targeted glioma therapy and SPECT imaging.
Evgenia Fotou, Adamantia Apostolopoulou, Christina‐Georgia Bika, Maria Giannakopoulou, Danai‐Efraimia Bajwa, Vassilios Moussis, Vassilios Tsikaris, Ioannis P. Gerothanassis, George A. Alexiou, Penelope Bouziotis, Andreas G. Tzakos   +10 more
wiley   +1 more source

Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent. [PDF]

Org Lett
Kushwaha P, Mantel M, Talbiersky P, Li Y, Sharma A, de la Torre BG, Albericio F.   +6 more
europepmc   +1 more source