Results 161 to 170 of about 38,750 (255)

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source

Straightforward Synthetic Approach to Aminoalcohols with 9-oxabicyclo[3.3.1]nonane or Cyclooctane Core via Nucleophilic Ring-Opening of Spirocyclic Bis(oxiranes). [PDF]

Molecules
Ryzhikova OV, Savchenkova DV, Kositov SV, Grishin YK, Maloshitskaya OA, Sedenkova KN, Averina EB.   +6 more
europepmc   +1 more source

Defined Nylon Oligomers Enable Mechanistic Insight Into Enzymatic Polyamide Depolymerization

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
The remarkable progress in enzymatic polyester depolymerization has demonstrated the potential of biocatalysis for sustainable polymer recycling. In contrast, enzymatic polyamide (PA) degradation remains poorly understood, largely due to the lack of defined and accessible model substrates.
Sukmanita Dewi, Hendrik Puetz, Ulrich Schwaneberg, Laura Hartmann   +3 more
wiley   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched <i>N</i>-Alkylpyridinium Salts as Piperidine Precursors. [PDF]

J Am Chem Soc
Selingo JD, King JR, Pio B, Neel AJ, Lam YH, Paton RS, Maddess ML, McNally A.   +7 more
europepmc   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu, François J. De Beer, Jolien Bertouille, Steven Ballet, Charlotte Martin, Ulrich Hennecke, Charlene Marais, Vladimir A. Azov   +7 more
wiley   +1 more source

Synthesis and biological evaluation of novel hydrazone derivatives for the treatment of Alzheimer's disease. [PDF]

RSC Adv
Ali SH, Osmaniye D, Kaplancıklı ZA.
europepmc   +1 more source

Syntheses of N-(Chlorobenzoylaminoalkyl)piperidines and N-(Chlorothiobenzoylaminoalkyl)piperidines

Nippon kagaku zassi, 1969
Kakuzo Isagawa, Takuji Hirose, Yasaburo Fushizaki   +2 more
openaire   +2 more sources

Electrolyte Design Strategies for Static Shuttle‐Free and Long‐Life Aqueous Zinc‐Iodine Batteries

Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.
This review systematically summarizes recent advances in electrolyte design for static aqueous Zn‐I2 batteries, highlighting solvation regulation and interfacial engineering strategies to control reaction kinetics, suppress iodine shuttling, enhance energy density, and stabilize multi‐electron iodine redox chemistry for durable, high‐performance energy
Qianqin Zhou, Fan Zhang, Ting Liao, Ziqi Sun   +3 more
wiley   +1 more source