Results 171 to 180 of about 38,750 (255)

Steering Amine-CO₂ Chemistry: A Molecular Insight into the Amino Site Relationship of Carbamate and Protonated Amine. [PDF]

ACS Omega
Nguyen TD, Chen X, Sharma R.
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Synthesis of 1,3-Bis-trifluoromethylated (Hetero)cyclohexane-2-carboxylates from Alkylidenemalononitriles. [PDF]

Org Lett
Mando M, Gogate AR, Smith DJ, Boyn JN, Grenning AJ.   +4 more
europepmc   +1 more source

Engineering Stealth Properties of Fluorescent Polymeric Nanoparticles by Short‐Chain Polysarcosine

Aggregate, Volume 7, Issue 6, June 2026.
To define the minimal polysarcosine chain length required for nanoparticle stealth properties, we engineered dye‐loaded polymeric nanoparticles functionalized with 5‐, 11‐, or 19‐mer peptoids. Only nanoparticles with 19‐mer polysarcosine achieved near‐neutral zeta potential, suppressed nonspecific interactions with glass surface and live cells ...
Tanushree Gupta, Quynh Anh Bui, Horgan Manirakiza, Lina El Hajji, Remi Pelletier, Nicolas Humbert, Abdel Wahab Mouhamad, Andreas Reisch, Arnaud Gautier, Andrey S. Klymchenko   +9 more
wiley   +1 more source

Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na_V1.8 Inhibitors. [PDF]

ACS Med Chem Lett
Dialer C, Krüger S, Wagener M, Mülbaier M, Peil S, Marigo M, Hagendorf S, Cao L, Molina CR, Morgan P, Young C, Ribeiro LR, Slynko I, Ritter S, Guberman M, Hass M, Klosky S, la Tendresse U, Gussmann C, Kühnert S, Peters S, Reichardt-Ockenfeld S, Depmeier H, Jakob F.   +23 more
europepmc   +1 more source

Azulene–BODIPY Hybrid Dyes as Non‐Emissive, Wide‐Gamut RGB Colorants for High‐Resolution Color Filters

Aggregate, Volume 7, Issue 6, June 2026.
Non‐emissive azulene–BODIPY hybrid dyes with tunable absorption and superior photothermal stability enable high‐resolution RGB color filters (8.2 µm) with wide‐gamut performance, near‐zero fluorescence, and low color difference (ΔEab < 3). ABSTRACT The pursuit of high‐performance color filters (CFs) for next‐generation displays demands organic dyes ...
Bo Yu, Shihao Zhang, Qi Li, Pengchen Du, Hanshen Xin, Jie Xue, Tengfei Yan, Jianhua Zhang   +7 more
wiley   +1 more source

Novel green synthesis of polyfunctionally substituted phthalazines promoted by visible light, DFT studies and molecular docking with antimicrobial and antibiofilm potency. [PDF]

Sci Rep
Mekheimer RA, Khalifa BA, Hashem ZS, Allam SMR, Sadek KU, Eletmany MR.   +5 more
europepmc   +1 more source

Mechanisms, Design Principles, and Emerging Strategies in Supramolecular Assembly‐Enabled Circularly Polarized Room‐Temperature Phosphorescence

Aggregate, Volume 7, Issue 6, June 2026.
The Graphical Abstract summarizes the key concepts of this review, covering supramolecular assembly strategies, CPP material integration, multicolor emission, information encryption, and flexible optoelectronic applications. ABSTRACT Circularly polarized luminescence (CPL) and room‐temperature phosphorescence (RTP) materials are crucial for advanced ...
Wei Zhang, Jiang‐Hai Li, Mao‐Qin Liu, Zheng‐Mei Cheng, Ye Meng, Yang Luo, Jin‐Liang Zhuang   +6 more
wiley   +1 more source