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1‐Azaspiro[3.3]heptane as a Bioisostere of Piperidine**

Angewandte Chemie - International Edition, 2023
1-Azaspiro[3.3]heptanes were synthesized, characterized, and validated biologically as bioisosteres of piperidine. The key synthesis step was thermal [2+2] cycloaddition between endocyclic alkenes and Graf's isocyanate, ClO2S-NCO, into spirocyclic β ...
Pavel K Mykhailiuk
exaly   +2 more sources

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Recent advancement of piperidine moiety in treatment of cancer- A review

European Journal of Medicinal Chemistry, 2018
Piperidine is an important pharmacophore, a privileged scaffold and an excellent heterocyclic system in the field of drug discovery which provides numerous opportunities in studying/exploring this moiety as an anticancer agent by acting on various ...
Ozair Alam, Dr Pallavi Jain, Farah Nawaz
exaly   +2 more sources

Poly(arylene piperidine)s with phosphoric acid doping as high temperature polymer electrolyte membrane for durable, high-performance fuel cells

Journal of Power Sources, 2019
The properties of high temperature polymer electrolyte membranes (HT-PEMs) are determined directly by the polymer matrix with phosphoric acid (PA) doping.
Hanqing Peng, Yan Xiang, Jin Zhang
exaly   +2 more sources

Quantum chemical and molecular dynamic simulation studies for the prediction of inhibition efficiencies of some piperidine derivatives on the corrosion of iron

Journal of the Taiwan Institute of Chemical Engineers, 2016
Savaş Kaya, Lei Guo, Cemal Kaya
exaly   +2 more sources

A brief overview on recent advances in spiro[chromane-2,4'-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research.

Bioorganic & Medicinal Chemistry, 2020
The spiro[chromane-2,4'-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of
Nitin Ghatpande, J. Jadhav, Rajshekhar V Kaproormath, M. Soliman, Mahidansha M. Shaikh   +4 more
semanticscholar   +1 more source

Recent development of piperazine and piperidine derivatives as antipsychotic agents.

Mini-Reviews in Medical Chemistry, 2020
Schizophrenia is a chronic neuropsychiatric disorder that affects nearly 1% of the global population. There are various anti-psychotic drugs available for the treatment of schizophrenia, but they have certain side effects, therefore there is a need to ...
Akash Rathore, V. Asati, S. Kashaw, Shivangi Agarwal, Deepa Parwani, Sushanta Bhattacharya, Chaitali Mallick   +6 more
semanticscholar   +1 more source

Synthetic approaches toward piperidine related structures: A review

Synthetic Communications, 2020
The current review covers explosive development of various synthetic approaches for piperidine scaffold and its analogues in the last few decades.
A. Bari, A. Iqbal, Z. Khan, S. Shahzad, M. Yar   +4 more
semanticscholar   +1 more source