Results 121 to 130 of about 38,750 (255)

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Synthesis of Tetrakis(amino)ethylene-Derived Organic Reductants via Thermal Decomposition of Tris(amino)methanes. [PDF]

Org Lett
Kim S, Jia X, Hazari N, Oniani D, Wedal JC.   +4 more
europepmc   +1 more source

Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care: Emergency Care Redesign

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Over 50% of persons living with dementia (PLWD) and their care partners (dyads) visit the emergency department (ED) every year. In the ED, healthcare professionals face complex challenges managing acute issues and symptoms of Alzheimer's disease and Alzheimer's disease–related dementias without provider training or in‐ED structures to ensure a
Afshana Hoque, Allison Cuthel, Corita R. Grudzen, Manish N. Shah, Abraham A. Brody, Jori E. Fleisher, Jennifer DiMascio‐Donohue, Katelyn McLain, Lin T. Tun, Julia Levine, Keith S. Goldfeld, Joshua Chodosh, ED‐LEAD Investigators, Lauren Abbate, Rebecca Anthopolos, Alicia Arbaje, Fernanda Bellolio, Jonathan Berkowitz, Andrea Blome, Erik Jonathan Blutinger, Justin Kenneth Brooten, Reed Caldwell, Christopher Caspers, Nathaniel Chin, Edward Cisek, Valerie Cotter, Jeremy Thomas Cushman, Dan David, Allison L. Ducharme‐Smith, Scott Dresden, Mary Ellen Dupont, Marie Carmelle Elie, Andra Farcas, Bucky Ferozan, Nicholas Genes, Cameron Gettel, Andrea Gilmore‐Bykovski, Elizabeth Goldberg, Scott Goldberg, Satheesh Gunaga, Heather Heaton, Courtney Jones, Maura Kennedy, Timmy Li, Joseph Miller, Brian Mittman, Kei Ouchi, Brian W Patterson, Jennifer Portz, Alex Quinones, Suzanne Ryer, Ashley Shreves, Michelle Simpson, Silas Smith, Payal Sud, Joe Suyama, Scotty Thomas, Victoria Vaughan Dickson, Ian Wittman, Nancy Wood   +59 more
wiley   +1 more source

Optoelectronic properties of piperidine under hydrostatic pressure, temperature, and the companion inhibition activity by DFT and molecular docking approaches. [PDF]

Sci Rep
Doulatpour N, Rahnamaye Aliabad HA, Sabbaghzadeh R, Azadparvar M.   +3 more
europepmc   +1 more source

Bridging the Gap Between the ED and Home: The Community Paramedic‐Led Transitions Intervention for Persons Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT More than 6 million persons living with dementia (PLWD) in the United States rely on the emergency department (ED) for unscheduled care, with up to half discharged home after treatment. The ED‐to‐home transition poses significant challenges for PLWD and their care partners (referred to as “dyads”), contributing to high rates of ED revisits and
Meghan Jenkins Morales, Stephanie Ricketts, Corita R. Grudzen, Abraham A. Brody, Joshua Chodosh, Keith Goldfeld, Manish N. Shah, ED‐LEAD Investigators, Lauren Abbate, Rebecca Anthopolos, Alicia Arbaje, Fernanda Bellolio, Jonathan Berkowitz, Andrea Blome, Erik Jonathan Blutinger, Justin Kenneth Brooten, Reed Caldwell, Christopher Caspers, Nathaniel Chin, Edward Cisek, Valerie Cotter, Jeremy Thomas Cushman, Dan David, Allison L. Ducharme‐Smith, Scott Dresden, Mary Ellen Dupont, Marie Carmelle Elie, Andra Farcas, Bucky Ferozan, Jori Fleisher, Nicholas Genes, Cameron Gettel, Andrea Gilmore‐Bykovski, Scott Goldberg, Elizabeth Goldberg, Satheesh Gunaga, Heather Heaton, Courtney Jones, Maura Kennedy, Timmy Li, Joseph Miller, Brian Mittman, Kei Ouchi, Brian W. Patterson, Jennifer Portz, Alex Quinones, Ashley Shreves, Michelle Simpson, Silas Smith, Payal Sud, Joe Suyama, Scotty Thomas, Victoria Vaughan Dickson, Ian Wittman, Nancy Wood   +54 more
wiley   +1 more source

Sulfinylnitrenes via Chemoselective S-N Bond Cleavage: Design, Synthesis, and Applications. [PDF]

Org Lett
Kafle P, Mukherjee R, Yasuda S, Sharma I.   +3 more
europepmc   +1 more source

Burden and Risk Factors of CGM‐Detected Hypoglycemia in Older Adults With Type 2 Diabetes

Journal of the American Geriatrics Society, EarlyView.
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Michael Fang, Natalie Rula Daya, Yein Jeon, Justin B. Echouffo‐Tcheugui, B. Gwen Windham, Scott Zeger, Elizabeth Selvin   +6 more
wiley   +1 more source

Total Synthesis of Ussuriedine via a Late-Stage Stevens Rearrangement: Implications for Biosynthesis. [PDF]

J Am Chem Soc
Baidilov D, Cassaidy KJ, Shin YJ, Rawal VH.   +3 more
europepmc   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, EarlyView.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Deciphering Cold Stress Resilience: Multiomics Insights in Contrasting Wheat Genotypes From the Western Himalayas

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan, Farkhandah Jan, Mukesh Rathore, Yogita Singh, Prexha Kapoor, Palak Chaturvedi, Arindam Ghatak, Palakurthi Ramesh, Upendra Kumar, Manoj Prasad, Sundeep Kumar, Sachin Rustgi, Wolfram Weckwerth, Sanjay Kalia, Rajeev Kumar Varshney, Reyazul Rouf Mir   +15 more
wiley   +1 more source