Results 81 to 90 of about 14,777 (274)

Development of a [3+3] Cycloaddition Strategy toward Functionalized Piperidines

, 2016
This paper describes a novel route to functionalized piperidines via a formal [3+3] cycloaddition reaction of activated aziridines and palladium−trimethylenemethane (Pd-TMM) complexes.
David A. Price (36138), Simon J. Hedley (1660999), Wesley J. Moran (1633177), Joseph P. A. Harrity (1299309)   +3 more
core   +2 more sources

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP² Functionalization of Aryl and Vinyl Electrophiles

Inorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule, Christian Frabitore, Tom Livinghouse   +2 more
doaj   +1 more source

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

Beilstein Journal of Organic Chemistry, 2010
The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay, Alexandra M. Z. Slawin, David O'Hagan   +2 more
doaj   +1 more source

N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study

Future Journal of Pharmaceutical Sciences, 2018
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh   +2 more
doaj   +1 more source

Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom

Beilstein Journal of Organic Chemistry, 2020
The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied.
Giovanna Zanella, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, Enrique Gómez-Bengoa   +4 more
doaj   +1 more source

Opportunities and challenges for direct C–H functionalization of piperazines

Beilstein Journal of Organic Chemistry, 2016
Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj   +1 more source

New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds

Marine Drugs, 2010
There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult,
Amir E. Wahba, Mark T. Hamann
doaj   +1 more source

Diastereoselective synthesis of some novel benzopyranopyridine derivatives

Beilstein Journal of Organic Chemistry, 2006
BackgroundThe formation of novel N-substituted-1,2,3,4-tetrahydro[1,3]-dioxolo-[6,7]-5H-[1]benzopyrano [3,4-c]pyridines were observed unexpectedly during the acid-mediated ketal removal of ethylenedioxy ketal protected 4-piperidones.
Pradeep K. Mohakhud, Sujeet M. R. Kumar, Vasanth M. R. Kumar, Ravi M. R. Kumar, Moses D. R. Babu, Vyas D. R. K, Om D. R. Reddy   +6 more
doaj   +1 more source

2,3,4-Trisubstituted piperidines. A stereocontolled approach [PDF]

, 2015
This thesis details a methodology utilising various synthetic pathways towards cyclisation precursors suitable for use in Prins and carbonyl-ene cyclisations to effect 2,3,4-trisubstituted piperidines.
Bergman, Zara Dominique
core   +3 more sources

Enantiopure Piperidines as Versatile Tools in Natural Products Synthesis

, 2004
Enantiopure Piperidines as Versatile Tools in Natural Products ...
D. Passarella, Passarella Daniele
core   +2 more sources