Results 81 to 90 of about 40,681 (241)
Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives [PDF]
Brazilian Journal of Medical and Biological ResearchThe chemical structure of piperidine has a unique ability to combine with other molecular fragments. This fact makes it possible to actively use it as an effective basis for the creation of new drug-like substances.
E.M. Satbayeva +10 more
doaj +1 more source
BMC Anesthesiology, 2020 Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination.
Li Jia +5 more
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Development of a [3+3] Cycloaddition Strategy toward Functionalized Piperidines
, 2016 This paper describes a novel route to functionalized piperidines via a formal [3+3] cycloaddition reaction of activated aziridines and palladium−trimethylenemethane (Pd-TMM) complexes.
David A. Price (36138) +3 more
core +2 more sources
Asymmetric synthesis of piperidines using the nitro-Mannich reaction [PDF]
, 2021 A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in the 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry.
Anderson, JC +3 more
core
BMC Pharmacology and Toxicology, 2018 Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules.
Moses N. Ngemenya +5 more
doaj +1 more source
Asymmetric Routes to Substituted Piperidines
, 1998 An overview of the main asymmetric routes to substituted piperidines is presented. A wide range of synthetic strategies have been developed, because of the ubiquitous nature of the piperidine sub-unit in natural products, and because of the biological ...
Millwood, Paula A. +2 more
core +1 more source
Efficient Routes to Chiral 2-Substituted and 2,6-Disubstituted Piperidines
, 2016 The syntheses of chiral 2-substituted and 2,6-disubstituted piperidines, and piperidin-2-ylphosphonates, via benzotriazole methodology are ...
Peter J. Steel (1724674) +3 more
core +2 more sources
InorganicsTreatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule +2 more
doaj +1 more source
Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles
Beilstein Journal of Organic Chemistry, 2010 The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay +2 more
doaj +1 more source