Results 21 to 30 of about 33,915 (216)

Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

Journal of Pharmacological Sciences, 2019
Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models.
Takehiro Kawashiri, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe   +4 more
doaj   +1 more source

Donepezil-induced psychosis: a cautionary report of a rare adverse reaction

European Psychiatry, 2023
Introduction Donepezil is an acetylcholinesterase inhibitor approved by the Food and Drug Administration for the treatment of dementia in Alzheimer’s disease. While it is not curative for Alzheimer’s disease, donepezil has been shown to improve symptoms
K. R. Hutchings, B. K. Hutchings, B. Ratnakaran, A. S. Kablinger   +3 more
doaj   +1 more source

Evaluation of the Binding Characteristics of [5-11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase

Journal of Pharmacological Sciences, 2003
Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied.
Yoshihito Funaki, Motohisa Kato, Ren Iwata, Eiko Sakurai, Eiichi Sakurai, Manabu Tashiro, Tatsuo Ido, Kazuhiko Yanai   +7 more
doaj   +1 more source

A Multicentre, Randomised, Open-Label, Prospective Study to Estimate the Add-On Effects Of Memantine as Ebixa® Oral Pump (Solution) on Language in Patients with Moderate to Severe Alzheimer’s Disease Already Receiving Donepezil (ROMEO-AD)

Neurology and Therapy, 2023
Introduction This multicentre, randomised, open-label, and prospective study aimed to evaluate the effectiveness of memantine (memantine solution) on speech function in patients with moderate to severe Alzheimer’s disease (AD) who were already on ...
Hee-Jin Kim, YongSoo Shim, Hyun Jeong Han, Byeong C. Kim, Kee Hyung Park, So Young Moon, Seong Hye Choi, Dong Won Yang, Bora Yoon, Eun-Joo Kim, Jee Hyang Jeong, Seol-Heui Han   +11 more
doaj   +1 more source

Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals. [PDF]

, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Cesinaro, Stefano, Esposito, Roberto, Frazzini, Valerio, Pieramico, Valentina, Sensi, Stefano L   +4 more
core   +2 more sources

Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Journal of Neuroinflammation, 2017
Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related
Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A. Kato, Akira Monji   +8 more
doaj   +1 more source

Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. [PDF]

PLoS ONE, 2017
This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive ...
Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen, Kuei-Ru Chou   +6 more
doaj   +1 more source

Cognitive performance of healthy young rats following chronic donepezil administration. [PDF]

, 2008
RATIONALE: Experimental studies have investigated the effects of chronic donepezil treatment on the behavioral deficits elicited by reduced activity or the loss of cholinergic neurons that occurs in aging or in models of dementia. However, few studies
Bartolo, P. DE, Cutuli, D, Federico, F, Foti, F, Gelfo, F, Mandolesi, L, Petrosini, L   +6 more
core   +1 more source

Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]

, 2017
Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat, Applegate, Richard, Araujo, Camila, Ho, Wing Mann, Huang, Lei, Reis, Cesar, Zhang, John H   +6 more
core   +3 more sources

Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Molecular Medicine, 2023
Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as ...
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn   +8 more
doaj   +1 more source