Results 231 to 240 of about 27,370 (335)

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, Volume 25, Issue 15, Page 42-49, August 2025.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Editorial on Special Issue "The Therapy of Alzheimer's Disease: Towards a New Generation of Drugs". [PDF]

Pharmaceutics
Chaves S, Santos MA.
europepmc   +1 more source

CHOLINESTERASE AND LIPASE IN THE AMOEBOCYTES, INTESTINAL EPITHELIUM AND HEART MUSCLE OF THE QUAHOG, VENUS MERCENARIA

, 1953
Sumner I. Zacks, John H. Welsh
openalex   +2 more sources

Inhibition of True Cholinesterase in TOCP Poisoning with Potentiation by ‘Tween 80’ [PDF]

, 1967
J. E. C. Hern
openalex   +1 more source

Does Radon act via the cholinergic anti-inflammatory signaling pathway in arthritic mice and mesenchymal stem cells? [PDF]

, 2013
Fournier, C., Layer, P. G., Thangaraj, G.   +2 more
core  

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Fermented Cassava Residue Meal Improves Meat Quality by Regulating Muscle Fiber and Enhancing Lipid Metabolism in Huanjiang Mini-Pigs. [PDF]

Animals (Basel)
Jiang H, Azad MAK, Zhu Q, Ni H, Kong X.
europepmc   +1 more source

A polarographic method for following the rates of cholinesterase-catalyzed hydrolyses of acetylthiocholine [PDF]

, 1965
Thomas H. Ridgway, Harry B. Mark
openalex   +1 more source

Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes

Aging Cell, Volume 24, Issue 8, August 2025.
(a) Mitochondria contain wild‐type (black)/mutant (red) mtDNA; exceeding the mtDNA mutation threshold compromises OXPHOS, potentially driving degeneration of neurons vulnerable to age‐related neurodegenerative disease. Cellular compensations that is, mtDNA copy number upregulation and crosstalk with nuclear DNA may fail, driving neurodegeneration ...
Eloise J. Stephenson, Laura J. Bailey, Stephen Gentleman, Helen Tuppen, Istvan Bodi, Claire Troakes, Christopher M. Morris, Tony M. Carr, Sarah Guthrie, Joanna L. Elson, Ilse S. Pienaar   +10 more
wiley   +1 more source

Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning [PDF]

, 2008
Buckley, N. A., Eddleston, M., Eyer, P., Sheriff, M. H. Rezvi, Worek, F.   +4 more
core   +1 more source