Results 241 to 250 of about 27,370 (335)

Microglia in Post‐Traumatic Brain Injury (TBI) Cognitive Impairment: From Pathological Changes to Therapeutic Approaches

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
This review systematically analyzes the multi‐stage dynamic pathological evolution of microglia and therapy strategies targeting microglia in PSCI, providing a new perspective for a deeper understanding of the microscopic mechanisms of the disease. ABSTRACT Background Traumatic brain injury (TBI), as a common and serious neurological disease, brings ...
Ningcen Li, Wenhui Lu, Limei Tang, Lina Zhu, Weibin Deng, Hang Liu, Changquan Huang, Jingying Jin, Jingjiao Zeng, Shitai Chen, Lianqi Geng, Xiuwu Hu, Liang Zhou   +12 more
wiley   +1 more source

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery. [PDF]

Beilstein J Nanotechnol
Mansurova EE, Maslennikov AA, Lyubina AP, Voloshina AD, Nizameev IR, Kadirov MK, Mikhailova AA, Mikshina PV, Ziganshina AY, Antipin IS.   +9 more
europepmc   +1 more source

THE INHIBITION OF CHOLINESTERASES BY 3‐(DIETHOXYPHOSPHINYLOXY)‐N‐METHYLQUINOLINIUM METHYLSULPHATE AND ITS TERTIARY BASE

, 1954
F Hobbiger
openalex   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, Volume 58, Issue 8, August 2025.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: In silico and in vitro approaches. [PDF]

Curr Res Struct Biol
Sadeghi M, Seyedebrahimi S, Ghanadian M, Miroliaei M.   +3 more
europepmc   +1 more source

A Review of Chronic Wounds and Their Impact on Negative Affect, Cognition, and Quality of Life

International Wound Journal, Volume 22, Issue 8, August 2025.
ABSTRACT Chronic wounds represent a substantial socioeconomic, financial, and psychological burden. We examine preclinical and clinical evidence assessing the impact of chronic wounds on negative affect, cognition, and quality of life and discuss potential mechanisms underlying the link between chronic wounds and negative affect and cognition. There is
Maria C. Redmond, Georgina Gethin, David P. Finn   +2 more
wiley   +1 more source

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer's Disease Drug Determination. [PDF]

Biosensors (Basel)
Ivanov A, Shamagsumova R, Larina M, Evtugyn G.   +3 more
europepmc   +1 more source

The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Acetylcholinesterase (AChE) inhibitors are a class of drugs to treat Alzheimer's disease (AD). Our study reveals that some AChE inhibitors, for example, tacrine, disrupt the proper assembly and transport of oligomeric forms of AChE, resulting in endoplasmic reticulum (ER) stress. The ER stress ultimately leads to cell apoptosis. This tacrine‐induced ER
Xiaoyang Wang, Yingjie Xia, Maggie Suisui Guo, Jiahui Wu, Ajiaikebaier Dilidaer, Jin Gao, Tina Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim   +8 more
wiley   +1 more source

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source