Results 221 to 230 of about 216,956 (381)

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

NDP52 deficiency accelerates chondrocyte degeneration through promoting pathogenic mitochondrial ROS via reverse electron transport. [PDF]

Redox Biol
Zhu Y, Xu Y, Xie D, Yu N, Chen J, Xia J, Mei Z, Jin Y, Hu C, Tang P, Jiang S, Jiang C, Song H, Hu Z.   +13 more
europepmc   +1 more source

Observations on the structural features of the chondrocytes in the hypertrophic zone.

, 1986
Shunichi Shibata
openalex   +2 more sources

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
wiley   +1 more source

<i>WNK2</i> variants associated with familial osteoarthritis alter the chondrocyte response to hyperosmotic stress. [PDF]

RMD Open
Veerabhadraiah SR, Matheson DJ, Honeggar M, Aslor C, Zelada AC, Stubben C, Stoddard GJ, Kazmers NH, Grunwald DJ, Jurynec MJ.   +9 more
europepmc   +1 more source

Type X collagen synthesis during in vitro development of chick embryo tibial chondrocytes. [PDF]

, 1986
Patrizio Castagnola, G Moro, Fiorella DESCALZI‐CANCEDDA, Ranieri Cancedda   +3 more
openalex   +1 more source

Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation

Advanced NanoBiomed Research, EarlyView.
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos, Matteo Battaglini, Gianni Ciofani   +2 more
wiley   +1 more source

Perillyl alcohol promotes autophagy by suppressing the PI3K-AKT-mTOR signalling pathway in osteoarthritic chondrocytes in vitro. [PDF]

Sci Rep
Zhao D, Nong J, Li X, Tan J, Liao R, Chen Q, Qiu M.   +6 more
europepmc   +1 more source

Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair

Journal of dentistry research, 2017
R. Hinton, Y. Jing, J. Jing, J.Q. Feng
semanticscholar   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source