Results 221 to 230 of about 171,876 (350)

Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1. [PDF]

Inflamm Res
Lehtola T, Pemmari A, Nummenmaa E, Valjus I, Hämäläinen M, Moilanen T, Vuolteenaho K, Moilanen E.   +7 more
europepmc   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Accelerated cartilage regeneration via chondrocyte metabolic reprogramming using nano-steroid-conjugated mesenchymal stem cells in osteoarthritis. [PDF]

Theranostics
Lee JY, Park JY, Kwon IA, Lim SH, Kim KB, Park JY, Kang YJ, Kim SH, Khang D, Choi JK.   +9 more
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Cell Co-Implantations With Chondrocytes for Cartilage Repair: A Systematic Review of <i>In Vivo</i> Results. [PDF]

Cartilage
Olijve WT, Penn TW, de Jong WC, Korpershoek JV, de Girolamo L, Brittberg M.   +5 more
europepmc   +1 more source

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia [PDF]

, 2011
Farhana E. Suleman, Benedetta Gualeni, Hannah J. Gregson, Matthew Leighton, Katarzyna A. Piróg, Sarah Edwards, Paul Holden, Ray Boot-Handford, Michael D. Briggs   +8 more
openalex   +1 more source

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu   +5 more
wiley   +1 more source

Loss of the miR-221/222 Cluster Promotes the Pathogenesis of Osteoarthritis in Inflamed Mouse Chondrocytes and Osteoarthritis Models. [PDF]

Inflammation
Liu X, Feng F, Jin Y, Ma C, Zhu Q, You Y, Gao M, Li X, Niu X, Wang J.   +9 more
europepmc   +1 more source

Treatment of large chondral lesions with an autologous minced cartilage technique and synovial flap leads to superior results compared to matrix associated autologous chondrocyte transplantation technique after 24 months: A controlled clinical trial

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Treating large cartilage lesions in the knee remains a challenge. While matrix‐associated autologous chondrocyte implantation (MACI) is the gold standard for medium to large lesions, the minced cartilage technique has shown promise in smaller defects. Enhancing this technique with biomaterials has been suggested for larger lesions, but
Johanna Mayr, Franziska Warth, Nicola Oehler, Martin Majewski, Christoph Lutter, Fabian Blanke   +5 more
wiley   +1 more source

NAT10-mediated ac4C modification of KDM1B drives osteoarthritis progression through epigenetic suppression of SOX9. [PDF]

Cell Mol Life Sci
Chen S, Ou W, Li X, Jie M, Zheng Y, Situ J, Liao Z, Huang L, Qi W, Ni S.   +9 more
europepmc   +1 more source