Results 151 to 160 of about 250,109 (264)

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Activity of chondroitin ABC lyase and hyaluronidase on free-radical degraded chondroitin sulfate

, 1995
High molecular mass-chondroitin sulfate was characterized for M(r), charge density and constituent disaccharides. This glycosaminoglycan was depolymerized by a controlled free-radical process mediated by hydrogen peroxide in the absence or presence of ...
VOLPI, Nicola, Venturelli T., Sandri I
core  

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We evaluated whether GPMs can also alter the capacity of annulus
K. Stradovnik‐Poikilidis, M. Teunissen, F. M. Riemers, M. van Doeselaar, J. Foolen, F. Abinzano, M. A. Tryfonidou, S. J. P. Callens, K. Ito   +8 more
wiley   +1 more source

Metabolic Fate of Exogenous Chondroitin Sulfate in Man

, 1991
Chondroitin sulfate is administered as a drug to man by intravenous, intramuscular or oral route. However, few data are available on the metabolic fate of exogenous chondroitin sulfate in man.
G. RONCA, M. DE BERNARDI, L. PALMIERI, G. MAUTONE, P. LUALDI, CONTE, Angela   +5 more
core  

Stromal Cell‐Derived Factor‐1α (SDF‐1α)‐Gene Activated Scaffold and Angiogenesis Process in Tissue Engineering: A Systematic Review and Meta‐Analysis of in Vitro Studies

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The current systematic review revealed that stromal cell‐derived factor‐1α (SDF‐1α)‐gene‐activated scaffolds have a beneficial impact on promoting SDF‐1α gene expression and protein production. However, this effect is not observed for vascular endothelial growth factor (VEGF) gene expression and protein quantity and endothelial formation, which may be ...
Tungki Pratama Umar, Dessy Agustini, Sandy Hasan, Rohan Sabloak   +3 more
wiley   +1 more source

Structural basis of chondroitin sulfate backbone polymer synthesis. [PDF]

Nat Commun
Tehrani D, Cortiella-Valls N, Huang C, Chapla D, Zheng Z, Venkat A, O'Boyle B, Kannan N, Perez C, Moremen KW.   +9 more
europepmc   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Chondroitin Sulfate-Based Self-Assembling Nanoprodrug for Controlled Methotrexate Delivery in Cancer Therapy. [PDF]

Molecules
Scorzafave L, Pellegrino M, Cirillo G, Fiore M, Pino R, Amantea D, Leggio A, Nicoletta FP, Iemma F, Curcio M.   +9 more
europepmc   +1 more source