Results 111 to 120 of about 7,722 (218)

In Vitro Validation of Pulsed Electromagnetic Field (PEMF) as an Effective Countermeasure Against Inflammatory‐Mediated Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
ABSTRACT Background Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain (LBP), the leading cause of disability worldwide, with a significant impact on the quality of life and health of common people. The etiology of IDD is still unclear, but it has been largely demonstrated the crucial role of inflammation and ...
Laura Guarnaccia, Laura Begani, Silvana Pileggi, Mauro Pluderi, Stefano Borsa, Claudia Fanizzi, Massimiliano Domenico Rizzaro, Giorgio Fiore, Laura Fontana, Rolando Campanella, Chiara Cordiglieri, Chiara Gaudino, Giovanni A. Alotta, Monica Miozzo, Emanuele Garzia, Emanuela Barilla, Lorenzo Fassina, Laura Riboni, Marco Locatelli, Giovanni Marfia, Stefania E. Navone   +20 more
wiley   +1 more source

Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc. [PDF]

Signal Transduct Target Ther, 2017
Collin EC, Carroll O, Kilcoyne M, Peroglio M, See E, Hendig D, Alini M, Grad S, Pandit A.   +8 more
europepmc   +1 more source

Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound

Smart Medicine, Volume 4, Issue 2, June 2025.
As a non‐invasive therapeutic modality, LIPUS demonstrates potential in mitigating OA progression. This review synthesizes current evidence of OA pathophysiology, summarizes the mechanism of LIPUS treatment of OA, and proposes synergistic strategies to advanced OA treatment.
Mengtong Guan, Xinyu Zhang, Xinhe Li, Bo Liao, Wang Han, Jindong Tan, Zijie Wang, Lichen Wang, Jieliang Shen, Xiaoyu Han, Dingqun Bai   +10 more
wiley   +1 more source

N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. [PDF]

Proc Natl Acad Sci U S A, 2017
Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A.   +7 more
europepmc   +1 more source

Basic Emollients for Xerosis Cutis in Atopic Dermatitis: A Review of Clinical Studies

International Journal of Dermatology, Volume 64, Issue S1, Page 13-28, June 2025.
ABSTRACT Xerosis cutis (dry skin) is a common and burdensome symptom of atopic dermatitis (AD). Topical emollients restore skin hydration and barrier function through the physicochemical properties of their nonactive constituents (e.g., glycerol, urea, lactic acid, liquid paraffin, petrolatum) and represent the mainstay of basic therapy for xerosis ...
Andreas Wollenberg, Sebastien Barbarot, Antonio Torrelo   +2 more
wiley   +1 more source

Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Meprin β was studied using mice overexpressing it in cortical and hippocampal neurons. N‐terminomics identified brevican, a key extracellular matrix protein associated with synaptic plasticity and memory, as a potential substrate of meprin β. Further analyses revealed that brevican levels are dependent on the catalytic activity of meprin β.
Maximilian Keller, Celine Gallagher, Simon Kreiselmaier, Kira Bickenbach, Ulrich Schmitt, Liana Marengo, Dayan Taghikhah, Mohammad Abukhalaf, Andreas Tholey, Christoph Becker‐Pauly, Thomas Mittmann, Claus U. Pietrzik   +11 more
wiley   +1 more source

Structural elucidation of fucosylated chondroitin sulfates from sea cucumber using FTICR-MS/MS. [PDF]

Eur J Mass Spectrom (Chichester), 2018
Agyekum I, Pepi L, Yu Y, Li J, Yan L, Linhardt RJ, Chen S, Amster IJ.   +7 more
europepmc   +1 more source

Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
The tetrasaccharide linkage region of proteoglycans is synthesized through a series of well‐controlled enzymatic reactions in nature. The expression, activity, and substrate profile of these biosynthetic enzymes and the latest development of chemoenzymatic synthesis of linkage region‐bearing glycopeptides are summarized in this review.
Po‐han Lin, Xuefei Huang
wiley   +1 more source

Conformational analysis of the oligosaccharides related to side chains of holothurian fucosylated chondroitin sulfates. [PDF]

Mar Drugs, 2015
Gerbst AG, Dmitrenok AS, Ustyuzhanina NE, Nifantiev NE.   +3 more
europepmc   +1 more source

Enzymatic Sulfation of Chondroitin B [PDF]

Journal of Biological Chemistry, 1960
Eugene A. Davidson, Joseph G. Riley
openaire   +2 more sources