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Matrix, 1993
Monoclonal antibodies have been developed that recognize epitopes in native chondroitin sulfate chains. One of these antibodies, CS-56, reportedly recognizes chondroitin 4- and 6-sulfates. However, this antibody, and four other anti-chondroitin sulfate antibodies, 4C3, 4D3, 6C3 and 7D4, do not recognize epitopes in chondroitin sulfate chains from Swarm
David A. Carrino +2 more
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Monoclonal antibodies have been developed that recognize epitopes in native chondroitin sulfate chains. One of these antibodies, CS-56, reportedly recognizes chondroitin 4- and 6-sulfates. However, this antibody, and four other anti-chondroitin sulfate antibodies, 4C3, 4D3, 6C3 and 7D4, do not recognize epitopes in chondroitin sulfate chains from Swarm
David A. Carrino +2 more
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Structure of Chondroitin Sulfate
2006Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Nikos K. Karamanos, Fotini N. Lamari
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Stability studies of chondroitin sulfate
Carbohydrate Research, 1999The stability of chondroitin sulfate (CS) was studied under acidic, neutral and basic conditions at 30 and 60 degrees C. CS is remarkably stable under neutral conditions at low temperature, while it degrades at 60 degrees C producing low-molecular-mass fragments and desulfated products. This decomposition process begins at ca.
VOLPI, Nicola +2 more
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Biosynthesis and function of chondroitin sulfate
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular and extracellular components that form regulatory milieu involving numerous biological and pathophysiological phenomena. Diverse functions of CSPGs can be mainly attributed to structural variability of their polysaccharide moieties, chondroitin sulfate glycosaminoglycans (CS-GAG ...
Hiroshi Kitagawa, Tadahisa Mikami
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Calcium binding by chondroitin sulfate
Calcified Tissue Research, 1968The binding of calcium by chondroitin sulfate C was studied by employing biological and physicochemical methods for the quantitative determination of ionic calcium. Mean values for logKj, the logarithm of the uncorrected formation constant for a calcium-chondroitin sulfate complex, were 1.64 with the frog heart technique, 1.55 with the murexide method,
Basil S. Strates +3 more
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Conjugation of chondroitin sulfates with amines
Russian Journal of Bioorganic Chemistry, 2008Conjugation of chondroitin sulfates with pharmacologically important amines in a water medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide was studied. Conjugates with amide and isoureidocarbonyl groups were synthesized.
E. S. Lukina +3 more
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Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides
2019Chondroitin sulfate (CS) and chondroitin sulfate proteoglycan (CSPG) belong to the glycosaminoglycan (GAG) family, a class of poly-anionic glyco-conjugates widely expressed by animal cells. They play important roles in many biological events. Here, we summarize the main considerations in the design of chemical and enzymatic methodologies to access ...
Xuefei Huang +2 more
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Chondroitin Sulfate Proteoglycans in the Brain
2006Publisher Summary Chondroitin sulfate proteoglycans (CSPGs) play important roles in the morphogenesis and maintenance of various tissues, including the central nervous system (CNS), through the interactions of their core proteins and/or chondroitin sulfate (CS) chains with cell adhesion molecules, extracellular matrix (ECM) molecules, and growth ...
Sachiko Aono, Atsuhiko Oohira
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Biosynthesis of Chondroitin/Dermatan Sulfate
IUBMB Life, 2002AbstractChondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation.
Jeremiah E. Silbert, Geetha Sugumaran
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Chondroitin Sulfate in Osteoarthritis Therapy
Orthopedics, 2009Despite the news of aid from chondroitin sulfate, recent research has questioned its efficacy in treating osteoarthritis.
Jonathan D Morris, Kelly M. Smith
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